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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1023Synthesis of Dinucleoside Triphosphates with...

Synthesis of Dinucleoside Triphosphates with Pyrimidine Bases

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Abstract:

A facile and efficient method for the synthesis of dinucleoside triphosphates with pyrimidine bases (Up₃U, Cp₃C, and Up₃C) from the corresponding nucleoside 5′-phosphoropiperidates has been developed. The experimental results indicated that the employment of 4,5-dicyanoimidazole (DCI) as the activator could notably promote the coupling reaction.

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Advanced Research on Energy, Chemistry, Materials and Informatization III

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Advanced Materials Research (Volume 1023)

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91-94

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https://doi.org/10.4028/www.scientific.net/AMR.1023.91

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Online since:

August 2014

Authors:

Qiang Wang, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, Cytidine, Dinucleoside Triphosphate, Phosphoropiperidate

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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[1] R.H. Garrett, C.M. Grisham, Biochemistry [M]. KY: Florence, 2008, Cengage Learning.

[2] A. Maton, J.J. Hopkins, L. Susan, Cells Building Blocks of Life Vol. 13 (1997), p.423476.

[3] E.G. Delicado, M.T. Miras-Portugal, L.M.G. Carrasquero, D.L.R. Perez-Sen, J. Gualix, Eur. J. Physiol. Vol. 452 (2006), p.563.

DOI: 10.1007/s00424-006-0066-5

[4] S.R. Shaver, J.L. Rideout, W. Pendergast, J.G. Douglass, E.G. Brown, J.L. Boyer, R.I. Patel, C.C. Redick, A.C. Jones, M. Picher, B.R. Yerxa, Purinergic Signalling Vol. 1 (2005), p.183.

DOI: 10.1007/s11302-005-0648-2

[5] V. Jankowski, M. van der Giet, H. Mischak, M. Morgan, W. Zidek, J. Jankowski, Br. J. Pharmcol. Vol. 157 (2009), p.1142.

DOI: 10.1111/j.1476-5381.2009.00337.x

[6] S.R. Shaver, J.L. Rideout, W. Pendergast, et al. Purinergic Signalling, Vol. 1 (2005), p.183.

[7] S. Hiroaki, W.S. Hiromichi, Masamitsu, Tetrahedron Lett. Vol. 32 (1991), p.6905.

[8] K.K. Nichols, B.R. Yerxa, D.J. Kellerman, Expert Opin. Investig. Drugs Vol. 13 (2004), p.47.

[9] S.R. Shaver, J.L. Rideout, W. Pendergast, J.G. Douglass, E.G. Brown, J.L. Boyer, R.I. Patel, C.C. Redick, A.C. Jones, M. Picher, B.R. Yerxa, Purinergic Signalling Vol. 1 (2005), p.183.

DOI: 10.1007/s11302-005-0648-2

[10] A. Hampton, T.T. Hai, F. Kappler, R.R. Chawla, J. Med. Chem. Vol. 25 (1982), p.801.

[11] N. Stern, D.T. Major, H.E. Gottlieb, D. Weizman, B. Fischer, Org. Biomol. Chem. Vol. 8 (2010), p.4637.

[12] H. Maruoka, M.P.S. Jayasekara, M.O. Barrett, D.A. Franklin, S. Castro, N. Kim, S. Costanzi, T.K. Harden, K.A. Jacobson, J. Med. Chem. Vol. 54 (2011), p.4018.

[13] H. Ko, R.L. Carter, L. Cosyn, R. Petrelli, S. De Castro, P. Besada, Y. Zhou, L. Cappellacci, P. Franchetti, M. Grifantini, S.V. Calenbergh, T.K. Harden, K.A. Jacobson, Bioorg. Med. Chem. Vol. 16 (2008), p.6319.

DOI: 10.1016/j.bmc.2008.05.013

[14] S. Yelovitch, J. Camden, G.A. Weisman, B. Fischer, J. Med. Chem. Vol. 55 (2012), p.437.

[15] W. Pendergast, B.R. Yerxa, J.G. Douglass, S.R. Shaver, R.W. Dougherty, C.C. Redick, I.F. Sims, J.L. Rideout, Bioorg. Med. Chem. Lett. Vol. 11 (2001), p.157.

DOI: 10.1016/s0960-894x(00)00612-0

[16] S.R. Shaver, J.L. Rideout, W. Pendergast, J.G. Douglass, E.G. Brown, J.L. Boyer, R.I. Patel, C.C. Redick, A.C. Jones, M. Picher, B.R. Yerxa, Purinergic Signalling Vol. 1 (2005), p.183.

DOI: 10.1007/s11302-005-0648-2

[17] Q. Sun, S.S. Gong, S. Liu, J. Sun, G.D. Liu, C. Ma, Tetrahedron Vol. 70 (2014), p.4500.