For Libraries For Publication Open Access Downloads About Us Contact Us
Paper Titles
Effect of Needle Punching Direction on Nonwoven Fiber Mat to the Mechanical Properties of Kenaf Reinforced Epoxy Composites Produced by Vacuum Assisted Resin Transfer Molding
p.267
Development of Silver-Coated Gold Nanoparticles and its Conjugation for Labeling on Lateral Flow Immunoassay
p.273
The Effect of Oxygen Precursor Concentration to the Iron Oxide Nanoparticles Properties for Lateral Flow Immunoassay Application
p.277
Crytallization and Properties of SiO2-Al2O3-K2O-ZrO2 Glass-Ceramics for Dental Applications
p.281
The Design of Elastin-Like Polypeptides (ELPs) as a Nanoparticulate-Based Therapeutic and Diagnostic Imaging Agent
p.287
Loading and Unloading Properties of Encapsulated Methylene Blue in Silica Nanoparticles for Photodynamic Applications
p.292
Poly (Vinyl Alcohol) in Fabrication of PLA Micro- and Nanoparticles Using Emulsion and Solvent Evaporation Technique
p.296
An In-Situ Functionalization of Decanethiol Monolayer on Thin Silica Coated Superparamagnetic Iron Oxide Nanoparticles Synthesized by Non-Seeded Process
p.300
Effect of Ageing Temperature on the Microstructures and Mechanical Properties of Ti-Nb Shape Memory Alloys
p.304

The Design of Elastin-Like Polypeptides (ELPs) as a Nanoparticulate-Based Therapeutic and Diagnostic Imaging Agent

Article Preview

Abstract:

The goal of our study is to develop genetically engineered polypeptides that self-assemble into nanoparticulates, which can present functional moieties on their exterior and sequester drugs and/or imaging agents within their interior. These particulates are intended to improve the detection and treatment of malignancy.

You might also be interested in these eBooks
Advancement of Materials and Nanotechnology III View Preview

Info:

Periodical:

Advanced Materials Research (Volume 1024)

Pages:

287-291

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1024.287

Citation:

Cite this paper

Online since:

August 2014

Authors:

Siti Najila Mohd Janib*, Radu O. Minea, Steve D. Swenson, ShuangLong Liu, Martha K. Pastuszka, Frank S. Markland, Peter S. Conti, ZiBo Li, J. Andrew Mackay

Keywords:

Cancer, Elastin-Like Polypeptide, Micelles, Nanoparticle, Positron Emission Tomography (PET)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2014 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

References

[1] E. Blanco, C.W. Kessinger, B.D. Sumer, J. Gao, Multifunctional micellar nanomedicine for cancer therapy, Exp Biol Med (Maywood), 234 (2009) 123-131.

DOI: 10.3181/0808-mr-250

Google Scholar

[2] D.W. Urry, Free energy transduction in polypeptides and proteins based on inverse temperature transitions, Prog Biophys Mol Biol, 57 (1992) 23-57.

DOI: 10.1016/0079-6107(92)90003-o

Google Scholar

[3] D.W. Urry, Physical Chemistry of Biological Free Energy Transduction As Demonstrated by Elastic Protein-Based Polymers†, The Journal of Physical Chemistry B, 101 (1997) 11007-11028.

DOI: 10.1021/jp972167t

Google Scholar

[4] J.A. Mackay, A. Chilkoti, Temperature sensitive peptides: engineering hyperthermia-directed therapeutics, Int J Hyperthermia, 24 (2008) 483-495.

DOI: 10.1080/02656730802149570

Google Scholar

[5] A. Chilkoti, T. Christensen, J.A. MacKay, Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology, Curr Opin Chem Biol, 10 (2006) 652-657.

DOI: 10.1016/j.cbpa.2006.10.010

Google Scholar

[6] E. Golemis, P.D. Adams, Protein-protein interactions : a molecular cloning manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., (2005).

DOI: 10.1134/s0006297906060162

Google Scholar

[7] S.M. Janib, M.F. Pastuszka, S. Aluri, Z. Folchman-Wagner, P.Y. Hsueh, P. Shi, Y.A. Lin, H. Cui, J.A. MacKay, A quantitative recipe for engineering protein polymer nanoparticles, Polymer Chemistry, (2014).

DOI: 10.1039/c3py00537b

Google Scholar

[8] S.M. Janib, S. Liu, R. Park, M.K. Pastuszka, P. Shi, A.S. Moses, M.M. Orosco, Y.A. Lin, H. Cui, P.S. Conti, Z. Li, J.A. MacKay, Kinetic quantification of protein polymer nanoparticles using non-invasive imaging, Integrative biology : quantitative biosciences from nano to macro, 5 (2013).

DOI: 10.1039/c2ib20169k

Google Scholar

[9] D. Chow, M.L. Nunalee, D.W. Lim, A.J. Simnick, A. Chilkoti, Peptide-based biopolymers in biomedicine and biotechnology, Materials Science and Engineering: R: Reports, 62 (2008) 125-155.

DOI: 10.1016/j.mser.2008.04.004

Google Scholar

[10] M. Haider, Z. Megeed, H. Ghandehari, Genetically engineered polymers: status and prospects for controlled release, J Control Release, 95 (2004) 1-26.

DOI: 10.1016/j.jconrel.2003.11.011

Google Scholar

[11] S.M. Janib, A.S. Moses, J.A. MacKay, Imaging and drug delivery using theranostic nanoparticles, Advanced Drug Delivery Reviews, 62 (2010) 1052-1063.

DOI: 10.1016/j.addr.2010.08.004

Google Scholar

[12] V.P. Torchilin, PEG-based micelles as carriers of contrast agents for different imaging modalities, Advanced Drug Delivery Reviews, 54 (2002) 235-252.

DOI: 10.1016/s0169-409x(02)00019-4

Google Scholar

[13] D.E. Meyer, G.A. Kong, M.W. Dewhirst, M.R. Zalutsky, A. Chilkoti, Targeting a Genetically Engineered Elastin-like Polypeptide to Solid Tumors by Local Hyperthermia, Cancer Research, 61 (2001) 1548-1554.

Google Scholar

[14] J. Andrew MacKay, M. Chen, J.R. McDaniel, W. Liu, A.J. Simnick, A. Chilkoti, Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection, Nat Mater, 8 (2009) 993-999.

DOI: 10.1038/nmat2569

Google Scholar

[15] W. Liu, M.R. Dreher, D.Y. Furgeson, K.V. Peixoto, H. Yuan, M.R. Zalutsky, A. Chilkoti, Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice, J Control Release, 116 (2006) 170-178.

DOI: 10.1016/j.jconrel.2006.06.026

Google Scholar

© 2025 Trans Tech Publications Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For open access content, terms of the Creative Commons licensing CC-BY are applied.
Scientific.Net is a registered trademark of Trans Tech Publications Ltd.