Loading and Unloading Properties of Encapsulated Methylene Blue in Silica Nanoparticles for Photodynamic Applications

Abstract:

In this report, we discussed the physical properties of encapsulated Methylene Blue (MB) by Silica Nanoparticles (SiNPs) intended for photodynamic therapy application. The aim of this discussion is to determine the suitable concentration of MB which can be delivered to the target area. Results shows that the size of SiNP is not affected by the change in MB concentration from out-diffusion process even when the concentration of loaded MB were reduce by more than 50 percent. The applicability of the encapsulated MB in SiNP was demonstrated on Red Blood Cells (RBCs) and the results were compared to those obtained from naked MB.

• Periodical: Advanced Materials Research (Volume 1024)
• Pages: 292-295
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1024.292
• Online since: August 2014
• Authors: Ghaseb N. Makhadmeh*, Azlan Abdul Aziz, Khairunisak Abdul Razak
• Keywords: Content Loading, Encapsulation, Methylene Blue, Silica Nanoparticles, Unloading

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