Development of Radioactive Sources on the Basis of Bioinert Ceramic Materials for Medical Applications and their Pre-Clinical Testing

Abstract:

In this article, both the composition and composite properties of radioactive sources for medical applications are worked out and studied. The bases of these sources are bioinert ceramic solids and radionuclides. The active source is constituted from dispersed radioactive yttriа oxide or strontium oxide monolithically encapsulated with bioinert glass flux. The thermal expansion properties of the analyzed composites are highly similar to the ones of both titanium metal and titanum alloys. Therefore, the developed radioactive sources can be mounted on titanium holder. Importantly, all utilized elements and alloys are already applied in medicine. In this article we demonstrate the use of a radioactive β-source placed on a titanium holder. The device is finally applied in a oncological model disease treatment.

• Periodical: Advanced Materials Research (Volume 1040)
• Pages: 286-291
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1040.286
• Online since: September 2014
• Authors: Tamara Khabas*, Ekaterina Kulinich, Victor Merkulov, Сhristoph Roesli, Mihail Martusevich
• Keywords: Ceramic, Glass, Live Tissue Reaction, Ophthalmic Applicator, Profilometry, Radiometric Measurements, Radionuclides

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