Effects of a Zr-Based Bulk Metallic Glass on the In Vitro Culture and Differentiation of Human Bone Marrow-Derived Mesenchymal Cells

Abstract:

The Zr-based bulk metallic glasses (BMGs) have excellent mechanical properties such as high strengths, low elastic moduli, and high hardness, can mitigate “stress shielding”effects and reduce the risk of “particle disease”.At the same time the Zr-based BMGs exhibit good corrosion resistance in a physiologically relevant environment. These properties provide a good opportunity for potential biomedical applications. In this article, the effects of a Zr-based amorphous alloy (Zr_60.5Al_8.9Fe_10.2Cu_10.2Ag_9.7Ti_0.5) on the in vitro culture and induced differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) are studied and in conclusion that Zr-based BMGs have a significant advantage in the human bone implant material for good biocompatibility.

• Periodical: Advanced Materials Research (Volume 1053)
• Pages: 431-437
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1053.431
• Online since: October 2014
• Authors: Wei Hua Xu*, Yun Ding, Xue Zhu Zhao
• Keywords: Biocompatibility, Human Mesenchymal Stem Cells, Zr-Based Bulk Metallic Glass

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