Solid-State Grafting of Poly(ethylene glycol) onto Alginic Acid

Siti Salimah Mohamad Ismail; Chan Chin Han; Tin Wui Wong

doi:10.4028/www.scientific.net/AMR.1060.180

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1060Solid-State Grafting of Poly(ethylene glycol) onto...

Solid-State Grafting of Poly(ethylene glycol) onto Alginic Acid

Abstract:

Melt reaction of poly (ethylene glycol) and alginic acid (guluronate-rich and mannuronate-rich) was studied. The poly (ethylene glycol) was end-capped with reactive amino group while the sodium alginate was converted to alginic acid before melt reaction. The melt reaction kinetics of poly (ethylene glycol) and alginic acid were monitored by differential scanning calorimetry. The reaction temperatures were ranged between 75 and 96 °C, below the degradation temperature of both parent polymers. The reactive amino group of poly (ethylene glycol) reacted with carboxyl group of alginic acid. The rate of reaction increased with reaction temperature.

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Periodical:

Advanced Materials Research (Volume 1060)

Pages:

180-183

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1060.180

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Online since:

December 2014

Authors:

Siti Salimah Mohamad Ismail, Chan Chin Han, Tin Wui Wong

Keywords:

Alginate, Melt Reaction, Poly(ethylene Glycol)

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References

[1] J. -S. Yang, Y. -J. Xie, and W. He: Carbohydrate Polymers Vol. 84 (2011), pp.33-39.

Google Scholar

[2] S.N. Pawar and K.J. Edgar: Biomacromolecules Vol. 12 (2011), pp.4095-4103.

Google Scholar

[3] M. Thompson, T. Vadala, M. Vadala, Y. Lin, and J. Riffle: Polymer Vol. 49 (2008), pp.345-373.

DOI: 10.1016/j.polymer.2007.10.029

Google Scholar

[4] D.A. Herold, K. Keil, and D.E. Bruns: Biochemical pharmacology Vol. 38 (1989), pp.73-76.

Google Scholar

[5] W. Tian, Q. Chen, C. Yu, and J. Shen: European Polymer Journal Vol. 39 (2003), p.1935-(1938).

Google Scholar

[6] S. Zalipsky: Advanced Drug Delivery Reviews Vol. 16 (1995), pp.157-182.

Google Scholar

[7] A. Richter and E. Åkerblom: International Archives of Allergy and Immunology Vol. 70 (1983), pp.124-131.

Google Scholar

[8] P. Laurienzo, M. Malinconico, A. Motta, and A. Vicinanza: Carbohydrate Polymers Vol. 62 (2005), pp.274-282.

DOI: 10.1016/j.carbpol.2005.08.005

Google Scholar

[9] N. Li, X. -R. Li, Y. -X. Zhou, W. -J. Li, Y. Zhao, S. -J. Ma, J. -W. Li, Y. -J. Gao, Y. Liu, X. -L. Wang, and D. -D. Yin: Biomaterials Vol. 33 (2012), pp.8881-8892.

Google Scholar

[10] Q. Wang, N. Zhang, X. Hu, J. Yang, and Y. Du: journal of Biomedical Materials Research Part A Vol. 2006 (2006), pp.122-128.

Google Scholar

[11] T. Pathak, J. Kim, S. -J. Lee, D. -J. Baek, and K. -J. Paeng: Journal of Polymers and the Environment Vol. 16 (2008), pp.198-204.

Google Scholar

[12] J.P. Soares, J.E. Santos, G.O. Chierice, and E.T.G. Cavalheiro: Ecletica Quimica Vol. 29 (2004), pp.57-63.

Google Scholar