Application of Eutectic Solvent to Preparation of Ibuprofen Suspension by Emulsion Evaporation Method

Abstract:

Menthol was used as sublimate eutectic compound to prepare the volatile eutectic solvent by mixing with camphor, borneol or N-Ethyl-5-methyl-2-(1-methylethyl) cyclohexanecarboxamide (WS-3). The system of menthol:camphor, menthol:borneol and menthol:WS-3 in various ratio (1:9 to 9:1) was characterized. The 5:5 menthol:camphor system showed the highest evaporation rate. Ibuprofen dissolved in eutectic solvent was used as internal phase of emulsion whereas tween80 was used as emulsifier. Eutectic solvent was evaporated to induce the transformation of emulsion droplet to small particle. Eutectic could be used as solvent for preparing small size suspension (14.81±0.44 µm) without organic solvent used.

• Periodical: Advanced Materials Research (Volume 1060)
• Pages: 188-191
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1060.188
• Online since: December 2014
• Authors: Sarun Tuntarawongsa, Thawatchai Phaechamud*
• Keywords: Emulsion Evaporation Method, Eutectic, Suspension

References

[1] A. Woolfson, R. Malcolm, K. Campbell, D. Jones and J. Russell: J. Control. Rel Vol. 67 (2000), pp.395-408.

[2] M. Bi, S. Hwang and K. Morris: Thermochim. Acta Vol. 404 (2003), pp.213-226.

[3] P. Stott, A. Williams and B. Barry: J. Control. Rel Vol. 50 (1998), pp.297-308.

[4] P. Stott, A. Williams and B. Barry: Int. J. Pharm Vol. 219 (2001), pp.161-176.

[5] C. Yong, Y. Oh, S. Jung, J. Rhee, H. Kim, C. Kim and H. Choi: Eur. J. Pharm. Sci Vol. 23 (2004), pp.347-353.

[6] S. Fiala, S. Jones and B. MB: Int. J. Pharm Vol. 393 (2010), pp.68-73.

[7] M. Lazerges, I. Rietveld, Y. Corvis, R. Céolin and P. Espeau: Thermochim. Acta Vol. 497 (2010), pp.124-128.

DOI: 10.1016/j.tca.2009.08.016

[8] H. Morrison, C. Sun and S. Neervannan: Int. J. Pharm Vol. 378 (2009), pp.136-139.

[9] D. Lindberg, M. de la Fuente Revenga and M. Widersten: J. Biotechnol Vol. 147 (2010), pp.169-171.

[10] R. Millers. U.S. Patent 20, 090, 247, 432. (2009).

[11] P. Domínguez de María and Z. Maugeri: Curr. Opin. Chem. Biol Vol. 15 (2010), pp.220-225.

[12] C. Wahlgren and H. Quiding: J. Am. Acad. Dermatol Vol. 42 (2000), pp.584-588.

[13] S. Nazzal, I. Smalyukh, O. Lavrentovich and M. Khan: Int. J. Pharm Vol. 235 (2002), pp.247-265.

[14] R. Pignatello, N. Ricupero, C. Bucolo, F. Maugeri, A. Maltese and G. Puglisi: AAPS. Pharm. Sci. Tech Vol. 7 (2006), p. E1-E7.

DOI: 10.1208/pt070127

[15] A. Dolenc, J. Kristl, S. Baumgartner and O. Planinsek: Int. J. Pharm Vol. 376 (2009), p.204–212.

[16] P. Lakshmi and G. Kumar: Int. J. Pharm. Pharm. Sci Vol. 2 (2010), pp.35-40.

[17] S. Tuntarawongsa and T. Phaechamud: Adv. Meter. Res Vol. 506 (2012), pp.355-358.

[18] S. Tuntarawongsa and T. Phaechamud: J. Met. Mat. & Min Vol. 22 (2012), pp.27-32.