It has been over ten years for the green chemistry and clean production became a popular research subject in China. The researchers have made astounding achievements in several sectors such as controlling pollution from the source, alleviating the influence of the chemical processes to the environment, contributing an important part to the development of modern chemical industry in China. The general scientific strategy research on intrinsic safety and clean production under the green chemistry framework is a must for China to develop a healthy chemical industry and to protect its environment. Through this research, we aim at establishing an effective and feasible scientific strategy for the coordinated development of clean production and intrinsic safety technology, extending beyond single research subject to get ideas and technology support from multiple academic sectors. Regarding the national science development strategy, we have put forward the coordinated development of intrinsic safety and clean production in combination with their common characteristics.