Development of the Binary Technologies for Radiation Therapy of Malignant Tumors – Current State and Problems

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The study analyses the current status and prospects of development of new radiation therapy methods, such as neutron capture therapy (NCT) and photon capture therapy (PCT), based on elements having high interaction cross section with radiations, to identify the benefits in their clinical application. One of the problems of NCT is the lack (or unavailability) of neutron sources with required intensity and spectrum. National Research Tomsk Polytechnic University has an opportunity of carrying out clinical studies, due to the presence of operating research nuclear reactor. However, the development of the medical neutron channel at this reactor is extremely challenging.

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369-372

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January 2015

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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[1] V.F. Khokhlov, I.N. Sheino, V.N. Kulakov et al., The Method Photon Capture Therapy of Malignant Tumors, Patent of Russian Federation, 2270045 (2006).

Google Scholar

[2] R.L. Moss, O. Aizawa, D. Beynon, R. Brugger, G. Constantine, O. Harling, H.B. Liu, P. Watkins. The requirements and development of neutron beams for neutron capture therapy of brain cancer, J. Neurooncol. 33 (1997) 27-40.

DOI: 10.1023/a:1005704911264

Google Scholar

[3] Current Status of Neutron Capture Therapy, IAEA, VIENNA, (2001), IAEA-TECDOC-1223.

Google Scholar

[4] O.K. Harling, K. J Riley. Fission reactor neutron sources for neutron capture therapy – a critical review, J. Neurooncol., 82 (2003) 7-17.

DOI: 10.1007/bf02699930

Google Scholar

[5] V.N. Mitin, V.N. Kulakov, V.F. Khokhlov, I.N. Sheino, A.M. Arnopolskaya, N.G. Kozlovskaya, K.N. Zaitsev, A.A. Portnov. Comparison of BNCT and GdNCT efficacy in treatment of canine cancer, Applied Radiation and Isotopes 67 (2009) 299–301.

DOI: 10.1016/j.apradiso.2009.03.067

Google Scholar

[6] V.N. Mitin, V.N. Kulakov, V.F. Khokhlov, I.N. Sheino, L.P. Bass, N.G. Kozlovskaya, K.N. Zaitsev, A. A Portnov, S.A. Yagnikov, S.V. Shiryaev, BNCT of canine osteosarcoma. 12th International Congress on Neutron Capture Therapy. October 9-13, Kagawa, Japan (2006).

DOI: 10.1504/ijnest.2004.005273

Google Scholar

[7] I.N. Sheino, Dose-supplementary therapy of malignant tumors. Ibid. (2006) 531-534.

Google Scholar

[8] A.A. Lipengolts, V.F. Khokhlov, V.N. Kulakov, T.A. Nasonova, O.A. Dobrynina, I.N. Sheino, Photon Capture Therapy – Process Analog of Neutron Capture Therapy. First Experimental Results of Melanoma Treatment in Mice. New Challenges in Neutron Capture Therapy. Proceedings of 14th International Congress on Neutron Capture Therapy, Buenos Aires, Argentina, October 25-29, (2010).

DOI: 10.1142/9789814338684_0003

Google Scholar