Possibility of Using Nuclear Track Membrane for Ophthalmology

Abstract:

This work is devoted to study the possibility of using a nuclear track membrane for ophthalmology in epithelial-endothelial corneal dystrophy treatment. Experiments were conducted using the track membrane “TOMTREK” based on polyethylenterephthalate (PET) with pores diameters (0.2-0.8)micron and (5x10⁶-2x10⁹) pores/cm² density. The pores were formed by irradiating the polymer PET ⁴⁰Ar⁺⁸ ions with energy 41.5 MeV. After irradiation, the membrane was chemically treated in the alkaline solution. Imparting hydrorhilicity membrane was the next step. Contact angle of the wettability the surface track membrane was measured just after the chemical treatment in NaOH and after 10 hours in air. The surface had been processed by the plasma self-sustained volume discharge to give the surface the hydrorhilic properties of the membrane. The maximum voltage on plasma discharge was 20-22 kV. The energy density in the discharge was 6·10^-4 J/cm² per pulse. Pulse repetition rate was 10³ s^-1. Samples of 6x6 cm were attached in a special rotating device. Thus, the effects were both surfaces of the membrane. After surface treatment, TM samples were placed in plastic bags. After a night contact angle of wetting was measured with these samples. Disks treating by the plasma were cut. The disk’s diameter was 6-8 cm. The edges of the disks were incised and processed with hot temperature in order to obtain the model of an appropriate shape. It was a shape of a truncated sphere with a certain radius of curvature. Then, the membrane was sterilized and implanted into the anterior chamber of the pig’s eye. Thus, we tested the methods of barrier keratoplasty using the nuclear track membrane.

• Periodical: Advanced Materials Research (Volume 1084)
• Pages: 434-437
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1084.434
• Online since: January 2015
• Authors: Ekaterina Bosykh*, Vladimir Pichugin, Valentina Sokhoreva
• Keywords: Cornea, Implantation, Keratoplasty, Permeability Keywords, Track Membrane

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