Possibility to Use the Radiopharmaceutical Based on the Gamma-Aluminum Oxide Labeled with ^99mTc to Identify Sentinel Lymph Nodes in the Experiment

Abstract:

Studying the possibility of using the radiopharmaceutical to identify sentinel lymph nodes were carried out on male rats. The preparation was injected subcutaneously in the I interfinger space of the right forelimb. Radiometry of rats’ organs showed that the studied preparation was actively accumulated in the axillary lymph node after subcutaneous injection. The experimental study of the pharmacokinetics of radiopharmaceutical based on gamma-oxide aluminum labeled with ^99mTc showed that the analyzed RPP can be successfully used for lymphoscintigraphy and visualization of sentinel node starting with the 15^th minute and up to the 24^th hour after subcutaneous injection.

• Periodical: Advanced Materials Research (Volume 1084)
• Pages: 443-446
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1084.443
• Online since: January 2015
• Authors: Vladimir Chernov, Anna Titskaya, Ivan Sinilkin, Roman Zelchan*, Natalya V. Varlamova
• Keywords: Gamma-Aluminum Oxide, Lymph Node, Lyophilisate, Radiometry, Radiopharmaceutical

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