Use of Autoleukocyte, Labelled with 99mTc-Exametazine for Evaluation of Inflammatory Changes in Myocardium

Svetlana I. Sazonova; Yuriy B. Lishmanov; Yuliya N. Ilyushenkova; Roman E. Batalov; Yuliya V. Rogovskaya

doi:10.4028/www.scientific.net/AMR.1084.511

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Use of Autoleukocyte, Labelled with ^99mTc-Exametazine for Evaluation of Inflammatory Changes in Myocardium
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Use of Autoleukocyte, Labelled with ^99mTc-Exametazine for Evaluation of Inflammatory Changes in Myocardium

Abstract:

Our purpose was to study possibilities of autoleukocyte, labelled in vitro with ^99m Tc-exametazine (^99m Tc-HMPAO), in evaluation of inflammatory changes of myocardium at patients with persistent form of atrial fibrillation (AF).We examined 30 patients with idiopathic persistent form of AF. For identification of the inflammatory areas in a myocardium before ablation scintigraphy (SPECT) ^99mTc-HMPAO – leucocytes was carried out. Upon completion of scanning a perfusion scintigraphy of a myocardium with a ^99mTc-methoxyisobutyl isonitrile (^99mTc-MIBI) (‘Tehnetril, ^99mTc’, JSC Diamed, Russia) in rest under the standard protocol was carried out. Pathologic accumulation of ^99mTc-HMPAO-leukocytes in a myocardium was revealed at 6 (20%) of the examined patients. Sensitivity of SPECT with ^99mTc-HMPAO-leukocytes in diagnostics of inflammatory changes of a myocardium, according to our data, was - 80%, specificity - 92%, diagnostic accuracy - 90%.

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Periodical:

Advanced Materials Research (Volume 1084)

Pages:

511-514

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1084.511

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Online since:

January 2015

Authors:

Svetlana I. Sazonova*, Yuriy B. Lishmanov, Yuliya N. Ilyushenkova, Roman E. Batalov, Yuliya V. Rogovskaya

Keywords:

^99mTc–HMPAO (Exametazine) - Autoleukocytes, ^99mTc-Methoxyisobutyl Isonitrile, Atrial Fibrillation, Myocarditis

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