Use of Single Photon Emission Computed Tomography (SPECT) with 99mTc-MIBI for Evaluation of Neoadjuvant Chemotherapy Effectiveness of Larynx and Laryngopharynx Cancer Treatment

Roman Zelchan; Vladimir Chernov; Anna Titskaya; Ivan Sinilkin; Svetlana Chizhevskaya; Evgeny T. Choynzonov

doi:10.4028/www.scientific.net/AMR.1084.519

Paper Titles

Use of ^99mTc-HMPAO in Evaluating Cerebrovascular Events in the Patients with Metabolic Syndrome: Relationship to Cognitive Function
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Use of Autoleukocyte, Labelled with ^99mTc-Exametazine for Evaluation of Inflammatory Changes in Myocardium
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Use of Pulse Oximetry in Radiotherapy
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Use of Single Photon Emission Computed Tomography (SPECT) with ^99mTc-MIBI for Evaluation of Neoadjuvant Chemotherapy Effectiveness of Larynx and Laryngopharynx Cancer Treatment
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Use of SPECT with ^99mTc-Pyrophosphate Combined with a Perfusion Myocardium Scintigraphy in the Evaluation of Inflammatory Changes of the Heart in Patients with Persistent Atrial Fibrillation
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Use of Technetium-99m-Labeled Lipophilic Complex of Methoxy-Isobutyl-Isonitrile and Iopromide Radiopaque Substance to Assess the Severity of Coronary Atherosclerosis in Patients with Coronary Heart Disease at Mild Disorders of Myocardial Perfusion
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Use of Technetium-99m-Labeled Methoxy-Isobutyl Isonitrile and Iodine 123-Labeled Phenyl-Methyl-Pentadecanoic Acid in the Diagnosis and Prognosis of Patients with Dilated Cardiomyopathy
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Use of Technetium-99m-Labelled Sodium Diphosphate Decahydrate to Assess Right Ventricle Dysfunction in Patients with Pulmonary Embolism
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1084Use of Single Photon Emission Computed Tomography...

Use of Single Photon Emission Computed Tomography (SPECT) with ^99mTc-MIBI for Evaluation of Neoadjuvant Chemotherapy Effectiveness of Larynx and Laryngopharynx Cancer Treatment

Abstract:

We study the possibility of using SPECT with ^99mTc-MIBI for the evaluation of the effectiveness of neoadjuvant chemotherapy for cancer of the larynx and laryngopharynx treatment. The study included 20 patients who have cancer of larynx or laryngopharynx. The patients underwent SPECT with ^99mTc-MIBI before treatment and after two courses of neoadjuvant chemotherapy. In processing the results indices tumor / submandibular salivary gland and tumor / parotid gland were calculated. These results indicate that in the group of patients with tumor regression of more than 30%, a decrease of the calculated parameters was also more than 30%. At the same time calculated indices showed a decrease of less than 30% in patients with tumor regression of less than 30% on a scale RESIST.

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Periodical:

Advanced Materials Research (Volume 1084)

Pages:

519-522

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1084.519

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Online since:

January 2015

Authors:

Roman Zelchan*, Vladimir Chernov, Anna Titskaya, Ivan Sinilkin, Svetlana Chizhevskaya, Evgeny T. Choynzonov

Keywords:

^99mTc-MIBI, Cancer of Laryngopharynx, Cancer of Larynx, Neoadjuvant Chemotherapy, Single Photon Emission Computed Tomography (SPECT)

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References

[1] I.V. Reshetov, V.I. Chissov, E.I. Trofimov, Hypopharynx cancer, Moscow, (2006).

Google Scholar

[2] E.I. Trofimov, E.M. Fuki, Larynx cancer: diagnosis and treatment, Medical Consultation: Scientific-Practical J. 3 (2006) 10-20 (Russian).

Google Scholar

[3] E.L. Choinzonov, M.R. Mukhamedov, L.N. Balatskaya, Larynx cancer. Modern aspects of treatment and rehabilitation, Publishing House NTL, Tomsk, (2006).

Google Scholar

[4] S.B. Alieva, S.I. Tkachev, I.A. Zaderenko, Chemoradiotherapeutic options for patients with locally advanced squamous cell carcinoma of the throat, Head and Neck Tumours 1 (2011) 26-30 (Russian).

Google Scholar

[5] V.P. Boikov, I.A. Gladilina, D. Yu. Pavlyuk, I.G. Strukov, Therapeutic tactics in hypopharynx cancer, Practical Oncol. 4 (1) (2003) 51-55(Russian).

Google Scholar

[6] R. Danielsson, A. Sanchez-Crespo, A. Pegerfalk, 99mTc-sestamibi uptake and histological malignancy grade in invasive breast carcinoma uptake and histological malignancy grade in invasise breast carcinoma, Eur. J. Nuc. Med. Mol. Imaging. 30 (5) (2003).

DOI: 10.1007/s00259-003-1132-2

Google Scholar

[7] V.M. Papantoniou, L. Nakopoulou, J. Christodoulidou, Correlation and multivariate regression analysis between Tc-99m DMSA and Tc-99m MIBI uptake and steroid receptors, proliferation, index, tumor size, age, malignant grade, P53 and c-ERBB-2 in primary breast cancer, Eur. J. Nuc. Med. 28 (8) (2001).

DOI: 10.1016/s0960-9776(03)80066-8

Google Scholar

[8] E.K. Pauwels, V.R. McCready, J.H. Stoot, D.F. van Deurzen, The mechanism of accumulation of tumour-localising radiopharmaceuticals, Eur. Jur. Nuc. Med. 25 (3) (1998) 277-305.

DOI: 10.1007/s002590050229

Google Scholar

[9] A. Giordano, J. Galli, L. Corina, Use of SPECT with 99mTc-Sestamibi in a patient affected by laryngeal carcinoma and parathyroid adenoma, Rev. Esp. Med. Nucl. 19 (3) (2000) 211-214.

Google Scholar

[10] A.A. Titskaya, The clinical use of radionuclide studies in comprehensive diagnostics and evaluation of the effectiveness of neoadjuvant chemotherapy in breast cancer, Abstract of thesis (doctor degree, in Russian), Tomsk, (2009).

Google Scholar