Obtaining Technetium-99m-Labeled Glucose Derivatives

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Abstract:

The possibility of obtaining and using technetium-99m-labeled glucose derivatives for the diagnosis of malignant tumors by the method of single photon emission computed tomography (SPECT) has been considered. The level of international and domestic developments on this topic has been analyzed. The authors made an attempt to develop pilot batches of lyophilizates on the basis of various glucose derivatives for further obtaining appropriate radiopharmaceuticals (RPC).

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567-571

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January 2015

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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[1] V.S. Skuridin, A.S. Semenov, Preparation of radionuclide labeled glucose derivative for the diagnosis of cancer, News of Higher Educational Institutions. Physics (in Russian). 56, 4/2 (2013) 264-267.

Google Scholar

[2] H.K. Lee, D.H. Moon, J.S. Ryu, J.S. Kim, S.J. Oh, U.S. Patent 2003/0120046 A. (2003).

Google Scholar

[3] S. K. Ozker, B.D. Collier, U.S. Patent 06099822A. (2000).

Google Scholar

[4] Y. Chen, Z.W. Huang, L. He, S.L. Zheng, J.L. Li, D.L. Qin, Synthesis and evaluation of a technetium-99m-labeled diethylentriaminepentaacetate-deoxyglucose complex 99mTc-DTPA-DG as a potential imaging modality for tumors, J. Appl. Radiat. and Isot. 64(3) (2006).

DOI: 10.1016/j.apradiso.2005.08.004

Google Scholar

[5] X. Chen, L. Li, F. Liu, B. Liu, Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor, J. Bioorg. Med. Chem. Lett. 16 (21) (2006) 5503–5506.

DOI: 10.1016/j.bmcl.2006.08.050

Google Scholar

[6] D. Cheng, M. Rusckowski, Y. Wang, Y. Liu, G. Liu, X. Liu, D. Hnatowich, A Brief Evaluation of Tumor Imaging in Mice with 99mTc-glucarate Including a Comparison with 18F-FDG, J. Curr. Radiopharm., 4 (1) (2011) 5-9.

DOI: 10.2174/1874471011104010005

Google Scholar

[7] M.M. Welling, R. Alberto, Performance of a 99mTc-labelled 1-thio-beta-D-glucose 2, 3, 4, 6-tetra-acetate analogue in the detection of infections and tumours in mice: a comparison with [18F]FDG, J. Nucl. Med. Commun., 31(3) (2010) 239-248.

DOI: 10.1097/mnm.0b013e32833501e4

Google Scholar

[8] D.J. Yang, C.G. Kim, N.R. Schechter, A. Azhdarinia, D.F. Yu, C.S. Oh, J.L. Bryant, J.J. Won, E.E. Kim, D.A. Podoloff, Imaging with 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents, J. Radiology. 226 (2) (2003).

DOI: 10.1148/radiol.2262011811

Google Scholar

[9] S.J. Oh, J.S. Ryu, E.J. Yoon, M.S. Bae, S.J. Choi, K.B. Park, D.H. Moon, 99mTc-labeled 1-thio-beta-D-glucose as a new tumor-seeking agent: synthesis and tumor cell uptake assay, J. Appl. Radiat. and Isot. 64(2) (2006) 207-215.

DOI: 10.1016/j.apradiso.2005.07.022

Google Scholar