Potential Antipyretic Agents from Plants: An Overview

Abstract:

Plants are well known for its various uses since ancient times. Plants contribution in various fields such as medical, pharmaceutical and food industry bring a lot of benefits to human capital. Especially in the medical field, plants are major contributors for medicinal drugs as it itself is rich in various medicinal agents. One of the illness that can be treated by using plants is fever. Fever can be treated by consuming non-steroids anti-inflammatory drugs (NSAIDS). However, excessive intake of synthetic drugs bring a lot of harm to the human body especially to the internal organs. Traditionally, various plant is used to cure fever, which directly indicate plants are the best sources of natural antipyretic. Thus, in this present review, activity of natural antipyretic extracted from various plants towards fever will be explained. In this review paper, Google Scholar, PubMed, ScienceDirect were the sources for the published article to collect information regarding antipyretic activity. A number of 32 articles on 10 plant species are found to address antipyretic activities. This review concludes that antipyretic activity can be found indicatively in various plants throughout the world.

• Periodical: Advanced Materials Research (Volume 1113)
• Pages: 382-387
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1113.382
• Online since: July 2015
• Authors: Siti Khairun Nissa Afiffudden*, Habsah Alwi, Ku Halim Ku Hamid
• Keywords: Antipyretic, Extraction, Fever, Medicinal Plants, Natural

References

[1] P. Ifesinachi, Mechanisms of fever in humans, Int. J. Microbiol. Immunol. Res., vol. 2, no. 5, p.37–43, (2013).

[2] L. A Greisman and P. A Mackowiak, Fever: beneficial and detrimental effects of antipyretics., Curr. Opin. Infect. Dis., vol. 15, no. 3, p.241–5, Jun. (2002).

DOI: 10.1097/00001432-200206000-00005

[3] B. S. A. Kumar, K. Lakshman, K. Jayaveera, D. S. Shekar, A. A. Kumar, and B. Manoj, Antioxidant and antipyretic properties of methanolic extract of Amaranthus spinosus leaves, Asian Pac. J. Trop. Med., vol. 3, no. 9, p.702–706, Sep. (2010).

DOI: 10.1016/s1995-7645(10)60169-1

[4] E. Tamiljothi, V. Ravichandiran, N. Chandrasekhar, and V. Suba, Pharmacognostic and preliminary phytochemical screening of leaves of Tecomaria capensis, vol. 1, no. 3, p.34–40, (2011).

[5] N. K. Saini and M. Singha, Anti-inflammatory, analgesic and antipyretic activity of methanolic Tecomaria capensis leaves extract, Asian Pac. J. Trop. Biomed., vol. 2, no. 11, p.870–874, (2012).

DOI: 10.1016/s2221-1691(12)60245-7

[6] P. & G. Abirami, A Review on Enicostemma littorale, Pharmacology, vol. 83, p.75–83, (2011).

[7] N. V Chandrasekharan, H. Dai, K. L. T. Roos, N. K. Evanson, J. Tomsik, T. S. Elton, and D. L. Simmons, COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression., Proc. Natl. Acad. Sci. U. S. A., vol. 99, no. 21, p.13926–31, Oct. (2002).

DOI: 10.1073/pnas.162468699

[8] B. N. Shah and A. K. Seth, Medicinal Plants as a Source of Anti-Pyretic Agents A Review, vol. 1, no. June, p.10–16, (2010).

[9] J. E. Okokon, P. a. Nwafor, G. O. Abia, and H. K. Bankhede, Antipyretic and antimalarial activities of crude leaf extract and fractions of Enicostema littorale, Asian Pacific J. Trop. Dis., vol. 2, no. 6, p.442–447, Dec. (2012).

DOI: 10.1016/s2222-1808(12)60097-8

[10] P. L. Ladda and C. S. Magdum, Vitex negundo Linn . : Ethnobotany , Phytochemistry and Pharmacology- A Review, vol. 1, no. 1, p.111–120, (2012).

[11] A. S. Vishwanathan and R. Basavaraju, A Review on Vitex negundo L . – A Medicinally Important Plant, vol. 3, no. June, p.30–42, (2010).

[12] J. R. Murthy, S. Venkataraman, R. Meera, K. S. Desmukh, N. Chidambaranathan, and P. Devi, Phytochemical investigation and Antipyretic activity of leaf extract of Vitex negundo Linn, vol. 2, no. 2, p.1068–1073, (2010).

[13] A D. Kshirsagar, K. G. Ingale, N. S. Vyawahare, and V. S. Thorve, Hygrophila spinosa: A comprehensive review., Pharmacogn. Rev., vol. 4, no. 8, p.167–71, Jul. (2010).

DOI: 10.4103/0973-7847.70912

[14] P. Arjun, J. Shivesh, and N. M. P, Pharmacognostical Standardization of Leaves of Hygrophila spinosa T . Anders, vol. 1, no. 2, (2009).

[15] J. Amit, K. Abhinav, M. Deepali, and K. Mastanaiah, ISSN 2230 – 8407 Review Article Review / Pharmacological Activity Of Platycladus Orieantalis, vol. 2, no. 11, p.58–61, (2011).

[16] J. P. Sharma, A. Srivastava, S. P. Thakur, P. K. Barpete, and S. Singh, International Journal Of Pharmacy & Life Sciences Herbal medicine as antipyretic : A comprehensive review, vol. 1, no. 1, p.18–22, (2010).

[17] A. Jaiswal, Amit., Sutar, Niranjan., Garai, Ranju., Pati, M. K. and Kumar, Antipyretic activity of Platycladus orientalis leaves extract, no. 1, p.175–178, (2011).

[18] R. V. Kumar, S. Kumar, S. Shashidhara, S. Anitha, and M. Manjula, Antioxidant and Antimicrobial Activities of Various Extracts of Michelia champaca Linn flowers, vol. 12, no. 4, p.413–418, (2011).

[19] P. Majumder, International Journal Of Comprehensive Pharmacy Phytochemical , Pharmacognostical And Physicochemical Standardization Of Peperomia pellucida ( L . ) HBK . STEM, vol. 02, no. 08, p.1–3, (2011).

[20] J. K. Mensah, J. O. Ihenyen, and M. O. Okhiure, Nutritional , phytochemical and antimicrobial properties of two wild aromatic vegetables from Edo State, J. Nat. Prod. Plant Resour., vol. 3, no. 1, p.8–14, (2013).

[21] A. Khan, M. Rahman, and S. Islam, Antipyretic Activity of Peperomia pellucida Leaves in Rabbit, vol. 32, p.37–41, (2008).

[22] C. Orwa, A. Mutua, and R. Kindt, Aleurites moluccana ( L . ) Willd . Euphorbiaceae Aleurites moluccana ( L . ) Willd ., vol. 0. p.1–5, (2009).

DOI: 10.17528/cifor/003393

[23] J. Niazi, V. Gupta, P. Chakarborty, and P. Kumar, Anti-inflammatory and antipyretic activity of aleuritis moluccana leaves, vol. 3, no. 1, p.35–37, (2010).

[24] L. Mohan, A. Mv, and M. Kumari, Review Article Ocimum Sanctum Linn ( Tulsi ) - AN OVERVIEW, vol. 7, no. 1, p.51–53, (2011).

[25] J. L. Godhwani and D. S. Vyas, Ocimum Sanctum : An Experimental Study Evaluating Its Anti-Inflammatory , Analgesic And Antipyretic Activity In Animals, J. Ethnopharmacol., vol. 21, p.153–163, (1987).

DOI: 10.1016/0378-8741(87)90125-5

[26] P. Prakash and N. Gupta, Review Article Therapeutic Uses Of Ocimum Sanctum Linn ( Tulsi ) With A Note On Eugenol And Its Pharmacological Actions : A Short Review, vol. 49, no. 2, p.125–131, (2005).

[27] A. Kumar, A. Rahal, S. Chakraborty, R. Tiwari, S. K. Latheef, K. Dhama, U. Pradesh, P. Deen, and D. Upadhayay, Ocimum sanctum ( Tulsi ): a miracle herb and boon to medical science – A Review, vol. 4, no. 7, p.1580–1589, (2013).

[28] J. L. Godhwani and D. S. Vyas, Ocimum ~ Sanctum : An Experimental Its Anti-Inflammatory , Analgesic Activity In Animals Study Evaluating inhibited acute as well as chronic inflammation in rats as tested by carrageenan-induced pedal edema and croton oil-induced granuloma and exudate , , vol. 21, p.153–163, (1987).

DOI: 10.1016/0378-8741(87)90125-5

[29] S. Muñoz-valenzuela, A. A. Ibarra-lópez, L. M. Rubio-silva, and H. Valdez-, Neem Tree Morphology and Oil Content, p.126–128, (2007).

[30] S. Jafari, S. Saeidnia, M. Reza, and S. Ardekani, Micromorphological and preliminary phytochemical studies of Azadirachta indica and Melia azedarach, p.690–697, (2013).

DOI: 10.3906/bot-1205-14

[31] T. Lokeshwar, S. Pankaj, B. Mukesh, and B. Vishnu, ISSN 2230 – 8407 Review On Neem ( Azadirachta Indica ): Thousand Problems One Solution, Int. Res. J. Pharm., vol. 2, no. 12, p.97–102, (2011).

[32] A. Patra, S. Jha, P. N. Murthy, A. V. D, P. Chattopadhyay, G. Panigrahi, and D. Roy, Anti-Inflammatory and Antipyretic Activities of Hygrophila spinosa T . Anders Leaves (Acanthaceae), Trop. J. Pharm. Res., vol. 8, no. November 2008, p.133–137, (2009).

DOI: 10.4314/tjpr.v8i2.44521