Influence of Rotation Rate of Collecting Roller on the Mechanical Property of PCL/SF Tubular Scaffolds

Jing Wan Luo; Zhen Ran Xia; Jing Qu; Yan Ni Yu; Jing Li; Ming Zhong Li

doi:10.4028/www.scientific.net/AMR.1120-1121.813

Paper Titles

Conjugation, Identification and Bionomics Analysis of EGFR Targeting Drug TGF α-Saporin as a Bioactive Stent Coating Material
p.793

Molecular Mechanism on Inhibition of MB Angiogenesis by Curcumin Blocking the Wnt/β-Catenin and NF-κB Signaling Pathway and Inhibiting the Expression of VEGFs/VEGFRs
p.798

Mechanisms of Plant Polyphenol Genistein on Regulation of EMT in Ovarian Carcinoma
p.803

Fabrication of Eprinomectin-Loaded PLGA Microspheres and their In Vitro Veterinary Release Profiles
p.807

Influence of Rotation Rate of Collecting Roller on the Mechanical Property of PCL/SF Tubular Scaffolds
p.813

Plant Compound Curcumin Mediates Calcineurin Activity to Upregulate ABCA1 Expression in a Model of Alzheimer’s Disease
p.821

Influence of Hydrodynamic Cavitation on the Viscosity of Raw Sugar Solution
p.826

Application Research of Lipid Microsphere Biological Carrier Material on Prescription of Tanshinone II a Lipid Microsphere by Central Composite Design-Response Surface Method
p.834

Effects and Comparison of Curcumin on Morphology Changes of Chronic Cerebral Hypoperfusion in Young and Aged Rats
p.842

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1120-1121Influence of Rotation Rate of Collecting Roller on...

Influence of Rotation Rate of Collecting Roller on the Mechanical Property of PCL/SF Tubular Scaffolds

Abstract:

The composite tubular scaffolds with highly oriented nanofibers used for vascular repair could improve the biomechanical properties of tubular scaffolds, satisfying the biomechanical requirement for the change of blood pressure and conducing to cell adhesion, migration and proliferation. The tubular scaffolds from poly(ε-caprolactone)(PCL) and silk fibroin (SF) composite nanofibers were successfully fabricated through electrospinning using cylindrical roller with an outer diameter (OD) of 3.0 mm. The influences of the collecting rotatation speeds on electrospun PCL/SF nanofibers orientation and radial/axial mechanical properties of the scaffolds were investigated. The results revealed that the electrospun PCL/SF tubular scaffolds fabricated at 1500 and 2000 r/min (linear velocity of 2.1, 2.8 m/s, respectively) possessed good arrangement around the circumferential direction of roller and sufficient radial strength and suture strength. The electrospun PCL/SF tubular scaffolds with circumferential-direction structure as a new vascular graft may be useful in vessel tissue engineering.

You might also be interested in these eBooks

Contemporary Approaches in Material Science and Materials Processing Technologies

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 1120-1121)

Pages:

813-820

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1120-1121.813

Citation:

Cite this paper

Online since:

July 2015

Authors:

Jing Wan Luo, Zhen Ran Xia, Jing Qu, Yan Ni Yu, Jing Li, Ming Zhong Li*

Keywords:

Electrospinning, PCL, Roller, Silk Fibroin, Tubular Scaffolds

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] Z. Cheng, S.H. Teoh, Surface modification of ultra thin poly (ε-caprolactone) films using acrylic acid and collagen, Biomaterials. 25 (2004) 1991-(2001).

DOI: 10.1016/j.biomaterials.2003.08.038

Google Scholar

[2] J.H. Kim, P.H. Choung, I.Y. Kim, Electrospun nanofibers composed of poly(ε-caprolactone) and polyethylenimine for tissue engineering applications, Mater. Sci. Eng. C. 29 (2009) 1725-1731.

DOI: 10.1016/j.msec.2009.01.023

Google Scholar

[3] C. Vepari, D.L. Kaplan, Silk as a biomaterial, Prog. Polym. Sci. 32 (2007) 991-1007.

Google Scholar

[4] L. Meinel, V. Karageorgiou, S. Hofmann, Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds, J. Biomed. Mater. Res. A. 71 (2004) 25-34.

DOI: 10.1002/jbm.a.30117

Google Scholar

[5] Y. Wang, D.J. Blasioli, H.J. Kim, Cartilage tissue engineering with silk scaffolds and human articular chondrocytes, Biomaterials. 27 (2006) 4434-4442.

DOI: 10.1016/j.biomaterials.2006.03.050

Google Scholar

[6] S. E, Wharram, X. Zhang, D.L. Kaplan, Electrospun silk material systems for wound healing, Macromol. Biosci. 10 (2010) 246-257.

DOI: 10.1002/mabi.200900274

Google Scholar

[7] X. Zhang, C.B. Baughman, D.L. Kaplan, In vitro evaluation of electrospun silk fibroin scaffolds for vascular cell growth, Biomaterials. 29 (2008) 2217-2227.

DOI: 10.1016/j.biomaterials.2008.01.022

Google Scholar

[8] J.M. Corey, D.Y. Lin, K.B. Mycek, Aligned electrospun nanoﬁbers specify the direction of dorsal root ganglia neurite growth, J. Biomed. Mater. Res. A. 83 (2007) 636-645.

DOI: 10.1002/jbm.a.31285

Google Scholar

[9] H.B. Wang, M.E. Mullins, J.M. Cregg, Creation of highly aligned electrospun poly-L-lactic acid ﬁbers for nerve regeneration applications, J. Neural. Eng. 6 (2009) 016001.

DOI: 10.1088/1741-2560/6/1/016001

Google Scholar

[10] J. Qu, Y. Liu, Y. Yu, Silk fibroin nanoparticales prepared by electrospray as controlled release carriers of cisplatin, Mater. Sci. Eng C. 44 (2014) 166-174.

DOI: 10.1016/j.msec.2014.08.034

Google Scholar

[11] J.C. Chang, G.M. Gurr, M.J. Fletcher, Structure-property and structure-function relations of leafhopper (Kahaono montana) silk, Aust. J. Chem. 59 (2006) 579-585.

DOI: 10.1071/ch06179

Google Scholar