Fabrication of Eprinomectin-Loaded PLGA Microspheres and their In Vitro Veterinary Release Profiles

Ying Ge Zhao; Rui Qiong Tian; Jing Zhang; Xiao Yang Liang; Qing Shang

doi:10.4028/www.scientific.net/AMR.1120-1121.807

Paper Titles

Experimental Study on Laser Melting of Cemented Carbide Coatings by High Velocity Oxy-Fuel Spraying
p.785

Conjugation, Identification and Bionomics Analysis of EGFR Targeting Drug TGF α-Saporin as a Bioactive Stent Coating Material
p.793

Molecular Mechanism on Inhibition of MB Angiogenesis by Curcumin Blocking the Wnt/β-Catenin and NF-κB Signaling Pathway and Inhibiting the Expression of VEGFs/VEGFRs
p.798

Mechanisms of Plant Polyphenol Genistein on Regulation of EMT in Ovarian Carcinoma
p.803

Fabrication of Eprinomectin-Loaded PLGA Microspheres and their In Vitro Veterinary Release Profiles
p.807

Influence of Rotation Rate of Collecting Roller on the Mechanical Property of PCL/SF Tubular Scaffolds
p.813

Plant Compound Curcumin Mediates Calcineurin Activity to Upregulate ABCA1 Expression in a Model of Alzheimer’s Disease
p.821

Influence of Hydrodynamic Cavitation on the Viscosity of Raw Sugar Solution
p.826

Application Research of Lipid Microsphere Biological Carrier Material on Prescription of Tanshinone II a Lipid Microsphere by Central Composite Design-Response Surface Method
p.834

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1120-1121Fabrication of Eprinomectin-Loaded PLGA...

Fabrication of Eprinomectin-Loaded PLGA Microspheres and their In Vitro Veterinary Release Profiles

Abstract:

To prolong the bioactivity of eprinomectin (EPM), a batch of EPM-loaded PLGA microspheres were fabricated by a solvent evaporation method. The morphology of resultant microspheres was observed with an S-4800-I scanning electron microscope (SEM). The EPM release behaviors were investigated with a dialysis method and fitted with Zero-order, First-order, and Higuchi dynamical models. The optimum formula, C_PVA 2.0 w/v%, stirring rate 1, 200 r/min, C_PLGA 4.0 wt%, and oil/water ratio 1/250, was obtained from single-factor experiments. SEM images suggested that the resultant microspheres were monodispersed spheres with a few micropores on their surfaces. Furthermore, more pores and hollows were observed in the degraded PLGA matrix. EPM-loaded PLGA microspheres showed the maximum release amount in the mixture of alcohol/PBS (4/6, v/v). The release process lasted for 30 d, which increased the bioactivity and insecticidal efficacy of EPM. Besides, microspheres with the diameter of 50 μm showed a better release behavior than those from 100 μm and 150 μm ones. Therefore, such method had a promising application on sustained release of veterinary medicine.

You might also be interested in these eBooks

Contemporary Approaches in Material Science and Materials Processing Technologies

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 1120-1121)

Pages:

807-812

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1120-1121.807

Citation:

Cite this paper

Online since:

July 2015

Authors:

Ying Ge Zhao, Rui Qiong Tian, Jing Zhang, Xiao Yang Liang, Qing Shang*

Keywords:

Bioactivity, EPM, Microspheres, PLGA, Release

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] W.L. Shoop, J.R. Egerton, C.H. Eary, H.W. Haines, B.F. Michael, H. Mrozik, P. Eskola, M.H. Fisher, L. Slayton, D.A. Ostlind, B.J. Skelly, R.K. Fulton, D. Barth, Eprinomectin: a novel avermectin for use as a topical endectocide for cattle, J. Int. Parasitol. 26 (1996).

DOI: 10.1016/s0020-7519(96)00123-3

Google Scholar

[2] L. Antonian, P. DeMontigny, P.G. Wislocki, An automated method for the determination of subnanogram concentrations of eprinomectin in bovine plasma. J. Pharm. Biomed. Anal. 16 (1998) 1363-1371.

DOI: 10.1016/s0731-7085(97)00183-0

Google Scholar

[3] .

Google Scholar

[3] K. Ural, B. Ulutas, S. Kar, Eprinomectin treatment of psoroptic mange in hunter/jumper and dressage horses: a prospective, randomized, double-blinded, placebo-controlled clinical trial. J. Vet. Parasitol. 156 (2008) 353-357.

DOI: 10.1016/j.vetpar.2008.06.018

Google Scholar

[4] R.S. Lucile, Determination of abamectin, doramenctin, emamectin, eprinomectin, ivermectin and moxidectin in milk by liquid chromatography electrospray tandem mass spectrometry. J. AOAC. Int. 89 (2006) 1088-1094.

DOI: 10.1093/jaoac/89.4.1088

Google Scholar

[5] A. Frank, S.K. Rath, S.S. Venkatraman, Controlled release from bioerodible polymers: effect of drug type and polymer composition. J. Control. Release. 102 (2005) 333-344.

DOI: 10.1016/j.jconrel.2004.10.019

Google Scholar

[6] J.F. Sutra, P. Galtier , M. Alvinerie, C. Chartier, Determination of eprinomectin in plasma by high-performance liquid chromatography with automated solid phase extraction and fluorescence detection. J. The. Analyst. 123 (1998) 1525-1527.

DOI: 10.1039/a802093k

Google Scholar

[7] S.S. Dukhin , M.E. Labib, Theory of effective drug release from medical implants based on the Higuchi model and physico-chemical hydrodynamics. J. Colloid. Surface. A. 409 (2012) 10-20.

DOI: 10.1016/j.colsurfa.2012.04.040

Google Scholar

[8] X.R. Song, Y. Zhao, S.X. Hou, F.Y. Xu, R.L. Zhao, J.Y. He, Z. Cai, Y.B. Li, Q.H. Chen, Dual agents loaded PLGA nanoparticles, Systematic study. J. Eur. Pharm. Bio-pharm. 69 (2008) 445-453.

DOI: 10.1016/j.ejpb.2008.01.013

Google Scholar