Mechanisms of Plant Polyphenol Genistein on Regulation of EMT in Ovarian Carcinoma

Abstract:

More and more studies have reported that epithelial-mesenchymal translation (EMT) plays key roles not only on genesis, development and metastasis, but also on drug-resistance of chemotherapy of tumor. Meanwhile, the fact that beta-catenin transfer from membrance and cytoplasm to nucleus is major steps in process of EMT [1]. Research found that Genistein would suppress Wnt/beta-catenin signal pathway though inhibiting beta-catenin translation [2]. Furthermore, our research showed that Genistein could decrease the expression of GSK-3beta in ovarian carcinoma cell SKOV3. Beta-catenin and GSK-3beta are important factors of EMT, which indicated that Genistein would regulate EMT signal pathway through beta-catenin and GSK-3beta, but the mechanism is not clear. So, there has been great interest in understanding the molecular mechanisms on the effect of Genistein.

• Periodical: Advanced Materials Research (Volumes 1120-1121)
• Pages: 803-806
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1120-1121.803
• Online since: July 2015
• Authors: Xiao Lin, Yu Li*
• Keywords: Epithelial-Mesenchymal Translation (EMT), Genistein, Ovarian Carcinoma

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