Recent trend for membrane bioreactor (MBR) operation was to apply a low sludge retention time (SRT) to decrease the fouling propensity and simplify the overall maintenance. However, the correct control and operation of MBRs under low SRT conditions were not well-established. In this study, modeling of MBR system for municipal wastewater treatment was evaluated using hybrid Activated Sludge Models 3 (ASM3), which helped in determining the control and operating strategies. The experiment-based, manual trial-and-error approach used to calibrate the hybrid ASM3 was verified to be useful for MBR modeling at 30 d sludge retention time (SRT). Furthermore, the consistency relationships among carbon oxygen demanded (COD), soluble microbial products (SMP) and mixed liquor suspended solids (MLSS) were established in the process of modeling, implying that the accurate simulation of MLSS were the prerequisites for the COD and SMP prediction.