Intercalation of Fenoprofen into Layered Double Hydroxide for the Formation of Controlled Release Anti-Inflammatory Drug

Siti Halimah Sarijo; Monica Limau Jadam; Faizah Md Saleh

doi:10.4028/www.scientific.net/AMR.1142.230

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1142Intercalation of Fenoprofen into Layered Double...

Intercalation of Fenoprofen into Layered Double Hydroxide for the Formation of Controlled Release Anti-Inflammatory Drug

Abstract:

Synthesis of a new hybrid nanocomposite materials, zinc-aluminium-fenoprofen, ZAF was successfully accomplished by self-assembly method with molar ratio of Zn to Al; R=2 at concentration of fenoprofen=0.3 M. As a result of the successful intercalation, the interlayer spacing expanded from 9.8 Å in the zinc-aluminium-layered double hydroxide, ZAL to 20.1 Å in the ZAF hybrid nanocomposite. The FTIR spectra of the ZAF show resemblance peaks of ZAL and fenoprofen indicating the inclusion of the organic compound into the LDH interlamellae. The percentage loading of the guest anion, fenoprofen in ZAL was estimated to be about 63.4% (w/w) calculated from the carbon content.

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2016 International Conference on Advanced Material Research and Application

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Advanced Materials Research (Volume 1142)

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230-233

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https://doi.org/10.4028/www.scientific.net/AMR.1142.230

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Online since:

January 2017

Authors:

Siti Halimah Sarijo, Monica Limau Jadam*, Faizah Md Saleh

Keywords:

Controlled Release, Fenoprofen, Intercalation, Layered Double Hydroxide

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