Various mixtures of different lubricants and preparation methods were investigated in order to find the best lubricant mixture for effervescent tablets. Methods: Lubrication effectiveness in two methods of granulation of standard effervescent formulation was tested by using mixtures of various percents of different lubricants. L- Leucine, Polyethylen glycol 6000 and SLS were used as lubricant. The hardness, disintegration time and abrasion for tablets which produced from each formulation were determined. All formulations were investigated for transparency and tastelessness after their complete disintegration of tablets in 200 ml of water. Results: The results show the best lubrication results were obtained by using a mixture of 2% w/w of L- Leucine and 3% w/w of PEG 6000 by ethanol granulation method.