Interface between Nanophotonics and Biotechnology: How the Near-Field Can Boost Proteomics Based on LSPR Nano Sensor
An novel optical nano biosensor based on gold capped nano-particles for detecting binding events between ligands and receptor molecules as well as interactions among proteins without use of labels has been presented in this paper. The optical properties of nano-sized gold particles exhibiting pronounced adsorption in the visible region which called as localized surface plasmon resonance (LSPR) have been exploited, whose peak wavelengths depended exquisitely on the refractive index of the surrounding. In comparison with surface plasmon resonance (SPR) technology, the optical nano biosensor possessed high sensitivity, surprisingly low “bulk effect”, ease of preparation, and low-cost polymer based fabrication, which opened a promising bioanalytical application in practice.
Liangchi Zhang, Chunliang Zhang and Tielin Shi
X. X. Huang et al., "Interface between Nanophotonics and Biotechnology: How the Near-Field Can Boost Proteomics Based on LSPR Nano Sensor", Advanced Materials Research, Vols. 139-141, pp. 1554-1557, 2010