Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure

Kui Lin Deng; Li Rong Dong; Yu E Shi; Yu Bo Gou; Qian Li; Shu Liang Wang

doi:10.4028/www.scientific.net/AMR.148-149.1427

Paper Titles

Preparation and Properties of Electrospun Cellulose Acetate Nanofiber Mats
p.1408

Preparation of Cu-Zn Alloy by High Energy Ball Milling of Elemental Copper and Zinc
p.1413

Effect of Ultrasonic Disperse on the Properties of Carbon Nanotubes Supercapacitors
p.1417

Asymmetry Analysis of Water Level Measured on Two Ends of Drum Boiler
p.1421

Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure
p.1427

Nanofibrous Membrane of Silk Fibroin/Cellulose Acetate Blend for Heavy Metal Ion Adsorption
p.1431

Synthesis of CuIn_xGa_1-xSe₂ Powder by High-Pressure Stirring Solvothermal Method
p.1436

Influence of External Factors on Anisotropic Growth Habit of ZnO Crystal
p.1440

Effects of Synthesis Parameters on Hydrothermal Synthesis of NaA Zeolite
p.1444

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 148-149Drug Release Behaviors of a pH/Temperature...

Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure

Abstract:

As a drug delivery carrier, a novel pH/temperature sensitive bead (pTSB) with core-shelled structure from poly(N-acryloylglycine) (PAG), copoly(N-acryloylglycine methyl este and N-acryloylglycine ethyl ester) was prepared by two steps. In pH=7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the pTSB was about 60.1 % within 500 mins, but this value only reached to 22.3 % in pH=2.1 PBS. The release behaviors of indomethacin from pTSB also exhibited a remarkable dependence on PAG content in the core. Additionally, the release rate of indomethacin was much faster at 18 oC than that at 37 oC due to the temperature sensitivity of poly(N-acryloylglycinates). The experimental results indicate that pTSB seems to have a potential application in the drug release system controlled via pH or temperature in the biomedical fields.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 148-149)

Pages:

1427-1430

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.148-149.1427

Citation:

Cite this paper

Online since:

October 2010

Authors:

Kui Lin Deng, Li Rong Dong, Yu E Shi, Yu Bo Gou, Qian Li, Shu Liang Wang

Keywords:

Core-Shelled Structure, Drug Release Behavior, pH/temperature Sensitive, Poly(N-Acryloylglycinate)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] I. M. El-Sherbiny, E. M. Abdel-Bary: J Appl Polym Sci Vol. 115 (2010) p.2828.

Google Scholar

[2] J. Chen, M.Z. Liu, S.P. Jin, H.L. Liu: Polym. Adv. Technol. Vol. 19 (2008) p.1656.

Google Scholar

[3] X.C. Chen, H. Song, T. Fang, et al: J Appl Polym Sci Vol. 116 (2010) p.1342.

Google Scholar

[4] K.L. Deng, H. b. Zhong, X.Y. Zheng, et al: Poly Adv Tech 2009, DOI: 10. 1002/pat. 1471.

Google Scholar

[5] I.M. El-Sherbiny, R.J. Lins, E.M. Abdel-Bary: Eur Poly J Vol. 41 (2005) p.2584.

Google Scholar

[6] K.L. Deng, H. Tian, P.F. Zhang, H.B. Zhong, X.B. Ren: J Appl Polym Sci Vol. 114 (2009) p.176.

Google Scholar

[7] A.Z. Chen, S.B. Wang, L.J. Weng: J Biomimetics, Biomater, Tissue Eng Vol. 3 (2009) p.25.

Google Scholar

[8] R. Jayakumar, R.L. Reis, J.F. Mano: Mater Sci Forum Vol. 514–516 (2006) p.1015.

Google Scholar