Drug Release Behaviors of a Novel Ph/Temperature Responsive Hydrogel with Jujube Cake-Like Structure
A novel jujube cake-like pH/temperature responsive hydrogel, as a drug delivery system, was prepared by two steps in this paper. The intelligent copolymer hydrogel (PME) was obtained from N-acryloylglycinate methyl ester (AGME) and N-acryloylglycinate ethyl ester (AGEE), using sodium laurate (SL) as an emulsifier and N, N '-methylenebisacrylamide (NMBA) as a crosslinking agent. Selecting indomethacin as a model drug, in vitro drug release behaviors were investigated at different temperatures, phosphate buffer solutions (PBS) and emulsifier content. The cumulative release of indomethacin from the pH/temperature sensitive hydrogel was apparently increased as the emulsifier content increased, the pH value increased and the temperature decreased. 48% indomethacin from the hydrogel PME was released in pH 7.4 PBS at 18 oC within 600 minutes, whereas only 17% indomethacin diffused into pH 2.1 PBS.
Xianghua Liu, Zhengyi Jiang and Jingtao Han
K. L. Deng et al., "Drug Release Behaviors of a Novel Ph/Temperature Responsive Hydrogel with Jujube Cake-Like Structure", Advanced Materials Research, Vols. 148-149, pp. 994-997, 2011