Drug Release Behaviors of a Novel Ph/Temperature Responsive Hydrogel with Jujube Cake-Like Structure

Kui Lin Deng; Qian Li; Xiao Hua Li; Yu Bo Gou; Li Rong Dong; Chun Yuan Huang

doi:10.4028/www.scientific.net/AMR.148-149.994

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 148-149Drug Release Behaviors of a Novel Ph/Temperature...

Drug Release Behaviors of a Novel Ph/Temperature Responsive Hydrogel with Jujube Cake-Like Structure

Abstract:

A novel jujube cake-like pH/temperature responsive hydrogel, as a drug delivery system, was prepared by two steps in this paper. The intelligent copolymer hydrogel (PME) was obtained from N-acryloylglycinate methyl ester (AGME) and N-acryloylglycinate ethyl ester (AGEE), using sodium laurate (SL) as an emulsifier and N, N '-methylenebisacrylamide (NMBA) as a crosslinking agent. Selecting indomethacin as a model drug, in vitro drug release behaviors were investigated at different temperatures, phosphate buffer solutions (PBS) and emulsifier content. The cumulative release of indomethacin from the pH/temperature sensitive hydrogel was apparently increased as the emulsifier content increased, the pH value increased and the temperature decreased. 48% indomethacin from the hydrogel PME was released in pH 7.4 PBS at 18 oC within 600 minutes, whereas only 17% indomethacin diffused into pH 2.1 PBS.