To get higher rate of medicinal active ingredients of Tibetan medicine, the high-energy ultrasonic extraction technology is used. But the effect mechanism of acoustic cavitation to the chemical structure of the drugs is not clear yet. It is because that the theoretical and experimental researches are not enough. The research contents: the impact mechanism of HI ultrasound to the chemical structure of extracts should be tested comparing with other extraction technology, and the chemical composition of extracts with the different sound field parameters, media conditions, and process parameters. The methods: the chemical structures of active ingredients of extracts are detected by means of HPLC with the HI ultrasonic and reflux boiling extraction technologies; ultrasonic type, frequency and power density are repeatedly adjust respectively; the ③changes of the chemical constituents of the Tibetan medicine extracts are detected. The optimized acoustic parameters are obtained. Based on the findings above, the symmetrical collective and high intensity ultrasound is established. The results: the bio-pharmaceutical active ingredients of Tibetan medicine will not be compromised with the ultrasonic extraction; the ability of SCHIU extraction of Tibetan medicine is 3 to 4 times more than conventional ultrasound extraction with the same extracting rate.