Preparation and In Vitro Evaluation of Carboxymethyl Konjac Glucomannan Coated 5-Aminosalicylic Acid Tablets for Colonic Delivery

Abstract:

Konjac Glucomannan(KGM) was denatured by Carboxylmethylation to prepare Carboxymethyl konjac glucomannan(CMKGM) as coating material of 5-aminosalicylic acid(5-ASA) tablets. The 5-ASA release properties of the tablets were measured in vitro in the gastrointestinal tract simulation environment and in buffer solutions with β-mannase of pH 6.8 at 37 ± 0.5 degrees. The properties of the CMKGM were analyzed by FTIR spectra, viscosity measurement and swelling measurement. The integrality of the 5-ASA was investigated by ultraviolet spectrometry. The viscosity and swelling showed that CMKGM has lower swelling and lower viscosity compared to KGM. 5-ASA was released least in stimulating gastric environment and in pH 6.8 phosphate buffers,while the preparation was fast released in pH 6.8 phosphate buffers with β-mannase. The preparation was released 14% after 4 hours in pH 6.8 phosphate buffers , at the same time the preparation in pH 6.8 phosphate buffers with 0.2u ml-1 β-mannase was released 97% in 12 hours.The results suggested that CMKGM may be a useful carrier of 5 –ASA for colon-specific delivery. It has a potential use for advanced controlled release.

• Periodical: Advanced Materials Research (Volumes 152-153)
• Pages: 1712-1715
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.152-153.1712
• Online since: October 2010
• Authors: Xiao Yan Long, Xue Gang Luo, Neng Wu Zou, Yong Hong Ma
• Keywords: 5-Aminosalicylic Acid, Carboxymethyl Konjac Glucomannan, Colon-Specific Delivery, In Vitro, Mannanase

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DOI: 10.1016/j.ejpb.2008.02.005