Chiral Recognizable Properties of Thermosensitive Poly(NIPA-co-NALPE) Hydrogels

Abstract:

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A serious of poly(NIPA-co-NALPE) hydrogels containing chiral group (L-Phenylalanine ethyl ester) were prepared by copolymerization of N-isopropylacrylamide(NIPA) and acrylic acid derivatived L-Phenylalanine ethyl ester (NALPE) in ethanol with different feed ratios. The kinetics adsorption approach, isothermal adsorption and chiral separation experiment of hydrogels on D/L-phenylalanine were investigated, and the results showed that the chiral hydrogels exhibited enantioselectivity for D/L-phenylalanine and the absorption capability increased with the rising temperature and increasing contents of NALPE due to the temperature-sensitive NIPA molecular chains and the chiral monomer NALPE, respectively. Furthermore, the poly(NIPA-co-NALPE) hydrogels were also used to separate DL-alanine and DL-tartaric acid, which suggested that the gels are also applicable to other chiral molecules besides DL-phenylalanine and have potential applications in separation of chiral drugs.

Info:

Periodical:

Advanced Materials Research (Volumes 160-162)

Edited by:

Guojun Zhang and Jessica Xu

Pages:

13-18

DOI:

10.4028/www.scientific.net/AMR.160-162.13

Citation:

J. J. Chen et al., "Chiral Recognizable Properties of Thermosensitive Poly(NIPA-co-NALPE) Hydrogels", Advanced Materials Research, Vols. 160-162, pp. 13-18, 2011

Online since:

November 2010

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Price:

$35.00

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