Development and Calibration of an Optical Magnetic Twisting Cytometry for Studying Nano-Dynamics of Living Cells

Feng Lin; Xue Mei Jiang; Qing Feng Liao; Ai Jing Song; Lin Hong Deng

doi:10.4028/www.scientific.net/AMR.160-162.1535

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Development and Calibration of an Optical Magnetic Twisting Cytometry for Studying Nano-Dynamics of Living Cells
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 160-162Development and Calibration of an Optical Magnetic...

Development and Calibration of an Optical Magnetic Twisting Cytometry for Studying Nano-Dynamics of Living Cells

Abstract:

We report the development and calibration of a built optical magnetic twisting cytometry (OMTC) system. The development includes hardware assembly and software integration. The system has been calibrated in terms of its noise characteristics. The results demonstrated that in current experimental condition the system performed satisfactorily with negligible noise level. The ASM cell also exhibited stiffening in response to mechanical stimulation due to continuous twisting of beads on the cell surface, providing a useful technique for studying the role of ASM cell mechanics in pathogenesis of respiratory disease such as asthma.

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Periodical:

Advanced Materials Research (Volumes 160-162)

Pages:

1535-1540

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.160-162.1535

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Online since:

November 2010

Authors:

Feng Lin, Xue Mei Jiang, Qing Feng Liao, Ai Jing Song, Lin Hong Deng

Keywords:

Airway Smooth Muscle Cell, Nano-Dynamics, Noise Characteristic, OMTC

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