C-grade steel has been widely used for parts of train wheel, train hook and other main parts with its predominant performance. That was mostly produced under high temperature and plastic deformation. In this paper, lots of experiments on the thermo-mechanical simulator Gleeble are operated, and the strain-stress curves under different deforming conditions are obtained. By the analysis of flow stresses under different conditions, the relationship among flow stress, temperature and strain rate as Sellers-Tegart equation is found, and the math model of C-grade steel at high temperature is established. The FEM code DEFORM has been used to simulate the forging process of train wheels. The numerical simulation results show that the first-stage forging parameters have quite important influence on the material distribution and the forge figuration of train wheel. It is necessary to determine the parameters in the pre-forming process reasonably. While, the influencing factors on the forming load are analyzed. The research shows that the heat parameters and the forging speed have influence on the forming load. Lower value of heat transfer coefficient and environment temperature, and lower speed at the ending stage could reduce the forming load significantly in the forging process of train wheels.