This paper presents research on mechanical behavior of frame-supported transfer beams with or without opening in the high-rise buildings using commercial finite element software ANSYS. The result indicated that the hole only impacted the local stress distribution of transfer beam. From the overall view, stress distribution of frame-supported transfer beam with or without opening was almost same. But hole undermined the whole working performance of transfer beam and reduced transfer beam bearing capacity. Influence of the hole as the result of the stress concentration on transfer beam maked the spot became weak part. This weak spot needed to be strengthened in the practical struction members.