This paper concerns printing cylinders of offset press. In addition to research mechanism of the printing pressure, the paper employs finite element analysis and distance-anti-calculating to simulate the status of contacted contacting-cylinders. Deflection curves in axial and circumferential and the 3D model on deflection of cylinder are get. The result shows that in printing course, under the influence of gravity and printing pressure, the flexural deformation of cylinder is caused in the axial direction. besides, while printing pressure is applied to circumferential different position of printing cylinder, because of complex sectional construction，circumferential deformation is also inconsistent, so printing pressure is distributed asymmetrically that printing pressure is not only no-uniform in axial, but also wave-like periods in circumferential. The paper optimizes cylinder structure and proposes a new cylinder with pterygoid stiffeners of heterogeneous distribution. Simulation results show that the circumferential flexural curve of the optimized cylinder is obviously smooth than the original one, and the flexural distortion of the circumferential location point corresponding decreases, which indicates the anti-bending stiffness of optimized cylinder is enhanced as well as the flexural deformation is reduced, and the value of the different circumferential position’s printing pressure tends to be uniform. The maldistribution of the circumferential position’s printing pressure is improved effectively, which contributed to the improvement of printing quality.