UV screen printing Photochromic ink mainly includes pre-polymer, monomer, Photochromic materials, Photoinitiator, etc, and the curing process of ink is that under the irradiation of UV light source, the liquid substances with chemical reactivity are rapidly changed to the solid state, in this reaction process, Photoinitiator can promote the advancement of reaction, therefore, Photoinitiator directly affect the curing performance of inks. The inks are respectively prepared by changing the quantity and type of Photoinitiator, and the curing speeds are tested. The result shows when the quantity of Photoinitiator is 10%, the curing performance of ink is the best. In addition, the formulation experiment is made by selecting three Photoinitiators with best curing performance. The result indicates that compared to other formulations, the ink can obtain the biggest curing speed only by Photoinitiator 907, and the optimal curing speed is 68m/min under curing power 100w/cm.