Preparation of β-Cyclodextrin Modified Poly(d,l-Lactic Acid) and its Blood Compatibility

Abstract:

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Aiming to develop a biomaterial with excellent biocompability, a novel β-cyclodextrin modified polylactic acid (PLA-β-CD) was synthesized by N-acylation reaction of MPLA (maleic anhydride modified poly(d,l-lactic acid)) using hydrophilic mono(6-(2-aminoethyl)-amino-6-deoxy)- β-cyclodextrin(β-CD-6-E) as acylating agent. Surface wettability and blood biocompatibility of PLA-β-CD were investigated. The tests indicated that the static water contact angle of PLA-β-CD was decreased from 76.7º to 72.1º comparing with PLA. The morphology of blood platelets adhered on the surface of PLA-β-CD was observed by scanning, and only a few platelets, round and not aggregated. The results revealed that the blood compatibility of PLA-β-CD was better than PLA.

Info:

Periodical:

Advanced Materials Research (Volumes 181-182)

Edited by:

Qi Luo and Yuanzhi Wang

Pages:

429-433

DOI:

10.4028/www.scientific.net/AMR.181-182.429

Citation:

J. J. Zhu et al., "Preparation of β-Cyclodextrin Modified Poly(d,l-Lactic Acid) and its Blood Compatibility", Advanced Materials Research, Vols. 181-182, pp. 429-433, 2011

Online since:

January 2011

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Price:

$35.00

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