Preparation of β-Cyclodextrin Modified Poly(d,l-Lactic Acid) and its Blood Compatibility

Jiu Jin Zhu; Xue Jun Quan; Yuan Liang Wang; Shu Shu Zou

doi:10.4028/www.scientific.net/AMR.181-182.429

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 181-182Preparation of β-Cyclodextrin Modified...

Preparation of β-Cyclodextrin Modified Poly(d,l-Lactic Acid) and its Blood Compatibility

Abstract:

Aiming to develop a biomaterial with excellent biocompability, a novel β-cyclodextrin modified polylactic acid (PLA-β-CD) was synthesized by N-acylation reaction of MPLA (maleic anhydride modified poly(d,l-lactic acid)) using hydrophilic mono(6-(2-aminoethyl)-amino-6-deoxy)- β-cyclodextrin(β-CD-6-E) as acylating agent. Surface wettability and blood biocompatibility of PLA-β-CD were investigated. The tests indicated that the static water contact angle of PLA-β-CD was decreased from 76.7º to 72.1º comparing with PLA. The morphology of blood platelets adhered on the surface of PLA-β-CD was observed by scanning, and only a few platelets, round and not aggregated. The results revealed that the blood compatibility of PLA-β-CD was better than PLA.

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Advanced Materials Science and Technology, ICMST 2010

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Periodical:

Advanced Materials Research (Volumes 181-182)

Pages:

429-433

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.181-182.429

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Online since:

January 2011

Authors:

Jiu Jin Zhu, Xue Jun Quan, Yuan Liang Wang, Shu Shu Zou

Keywords:

Platelet Adhesion, Poly(lactic acid) (PLA), β-Cyclodextrin Modified Polylactic Acid

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