Industrial Ecology (IE) is a creative way to achieve sustainable development. Marine resource-based chemical industry is the chemical industry which utilizes marine as its main raw materials. It is usually the dominate industry in coastal regions. Water flow is an important material flow for marine resource-based chemical industry. This article describes an example of the water utilization of the Hai Hua industrial ecosystem (HHIE). HHIE is an important marine resource-based chemical industry base in China. There are three kinds of water in HHIE: underground brine, seawater and freshwater. The three-fold of water utilization in HHIE is described. The basic approaches and the limiting factors of water utilization in HHIE are analyzed. It can provide some experiences for water utilization of other marine resource-based chemical industries.