This paper presents the prediction of a statistically analyzed model for the surface roughness,R_a of end-milled Machinable glass ceramic (MGC). Response Surface Methodology (RSM) is used to construct the models based on 3-factorial Box-Behnken Design (BBD). It is found that cutting speed is the most significant factor contributing to the surface roughness value followed by the depth of cut and feed rate. The surface roughness value decreases for higher cutting speed along with lower feed and depth of cut. Additionally, the process optimization has also been done in terms of material removal rate (MRR) to the model’s response. Ideal combinations of machining parameters are then suggested for common goal to achieve lower surface roughness value and higher MRR.