Preparation and Characterisation of TAM-PLGA Microspheres by Solvent Evaporation

Abstract:

Uniformly sized microspheres of poly(d, l-lactic-co-glycolic) (PLGA) encapsulating tamoxifen(TAM) were successfully prepared by solvent evaporation. In this study three different polylactide-co-glycolides were used with differing lactide-glycolide ratios (50:50, 75:25, and 85:15, respectively). The sphere size distribution and morphology was analyzed using Laser Particle Size Analyzer and SEM. The drug loading and release in vitro of the microspheres were also investigated. The result showed that the microspheres have good spherical and better sustained release.

• Periodical: Advanced Materials Research (Volumes 194-196)
• Pages: 558-561
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.194-196.558
• Online since: February 2011
• Authors: Bai Li Shu, Xu Ming Xue, Qi Meng Zhang, Ying Li Liu, Zong Hui Ma, Hua Li Nie, Li Min Zhu, Ling Yun Du
• Keywords: Drug Delivery, Micro-Sphere, PLGA, Solvent Evaporation, Tamoxifen

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