In this paper, we focus on the need for researching the performance of clothing materials. It chose the knitting fabric to be the object of study, and took the performance tests, which include basic performance, style, comfort and clothing comfort. After that, it analysis that these three variables— “fibers”, “yarn properties” and “fabric performance”— influence clothing thermal-wet comfort. The statistic analyses include one-way ANOVE, correlation analysis and principal component analysis. Based on the contrastive analysis of test results, it can be gain the effect of these three variables on clothing comfort.