Synthesis of Antiulcerative Drug Tenatoprazole

Feng Yan; Kai Qi Fan; Cheng Chi; Jin Guan

doi:10.4028/www.scientific.net/AMR.233-235.160

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 233-235Synthesis of Antiulcerative Drug Tenatoprazole

Synthesis of Antiulcerative Drug Tenatoprazole

Abstract:

An improved synthetic approach of tenatoprazole, an antiulcerative drug, is reported. The first step in this synthesis involves the coupling of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine with 2-chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride to afford sulfide 4, and the subsequent step of oxidation using substoichiomitric amount of hydrogen peroxide to give sulfoxide 1 quantitatively. The overall yield is around 80% for both two-step synthesis. The progress in this process is no purification process and affords the target compound with 99% purity by HPLC.

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Advanced Materials Research (Volumes 233-235)

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160-164

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https://doi.org/10.4028/www.scientific.net/AMR.233-235.160

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May 2011

Authors:

Feng Yan, Kai Qi Fan, Cheng Chi, Jin Guan

Keywords:

Hydrogen Peroxide, Oxidation, Sulfoxide, Tenatoprazole

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