Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers

Abstract:

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Polyethylene Glycol Oleate was synthesized by esterification of polyethylene glycol and Oil acid using DMAP as a catalyst. The double bonds of the product in the core of micelles were cross-linked by the initiation of (NH4)2S2O8 during the micelles formed. Applications of the noncross-linked and cross-linked polyethylene glycol oleate in drug delivery were studied, which indicates that drug efficiency decreased after micelles were core cross-linked, but release rate of MTX from core cross-linked micelles seems slower than that from noncross-linked micelles.

Info:

Periodical:

Advanced Materials Research (Volumes 236-238)

Edited by:

Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao

Pages:

1770-1774

DOI:

10.4028/www.scientific.net/AMR.236-238.1770

Citation:

Y. L. Guo et al., "Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers", Advanced Materials Research, Vols. 236-238, pp. 1770-1774, 2011

Online since:

May 2011

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Price:

$35.00

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