Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers

Yan Ling Guo; Bao Qi Wang; Jun Zhao; Zhao Shan Cui

doi:10.4028/www.scientific.net/AMR.236-238.1770

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Cathodic Polarization Behavior and Deposit Structure of Jet Electrodeposition Nickel
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Study on the Preparation and Properties of PAA/BC/Na-MMT Composites
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Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers
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Reducing Microbiological Adhesion on Aluminum by Using Silver Nanocrystals Encapsulated in Mesoporous Silica Nanoparticles
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Synthesis, Characterization and In Vitro Anticancer Activity of Two Novel Series of Organotin Retinoates
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Carboxymethy Chitosan Grafted Ricinoleic Acid Group for Nanopesticide Carriers
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Antibacterial Properties of M3+-TiO2 Thin Films by RF Magnetron Co-Sputtering
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 236-238Core Cross-Linked Polyethylene Glycol Oleate...

Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers

Abstract:

Polyethylene Glycol Oleate was synthesized by esterification of polyethylene glycol and Oil acid using DMAP as a catalyst. The double bonds of the product in the core of micelles were cross-linked by the initiation of (NH₄)₂S₂O₈ during the micelles formed. Applications of the noncross-linked and cross-linked polyethylene glycol oleate in drug delivery were studied, which indicates that drug efficiency decreased after micelles were core cross-linked, but release rate of MTX from core cross-linked micelles seems slower than that from noncross-linked micelles.