Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers
Polyethylene Glycol Oleate was synthesized by esterification of polyethylene glycol and Oil acid using DMAP as a catalyst. The double bonds of the product in the core of micelles were cross-linked by the initiation of (NH4)2S2O8 during the micelles formed. Applications of the noncross-linked and cross-linked polyethylene glycol oleate in drug delivery were studied, which indicates that drug efficiency decreased after micelles were core cross-linked, but release rate of MTX from core cross-linked micelles seems slower than that from noncross-linked micelles.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Y. L. Guo et al., "Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers", Advanced Materials Research, Vols. 236-238, pp. 1770-1774, 2011