Study on Biodegradable Implant with Poly (l-Lactic Acid) and its Releasing Character In Vitro

Abstract:

To elucidate the effects of implants fabricated by three-dimensional printing (3DP) technologies, a novel technique enables the complex implant release profiles, precise dosage control and rapid formulation in a single form. In this study, a unique implant with polylactic acid-based polymer powders was developed by the process. Test of the morphology and the releasing experiments in vitro of the implants were done to evaluate the implant devices. At about 100-day release of the implants in vitro, the drug concentration was measured and the profiles were made. The morphology of the implants of both technologies was characterized by three dimensional stereoscopy and environmental scanning electron microscope. The release behaviour and the microstructure were detected to compare the effects. 3DP technology allows the design and fabrication of implants with a novel micro- and macro-architecture which cannot be fabricated or may be fabricated with many difficulties in conventional technology.

• Periodical: Advanced Materials Research (Volumes 236-238)
• Pages: 2744-2747
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.236-238.2744
• Online since: May 2011
• Authors: Wei Dong Huang, Sheng Fang Li, Tao Zou, Xian You Xia
• Keywords: Biodegradation, Implant, Poly(lactic acid) (PLA), Release in Vitro

References

[1] Sarah LT, Tejal AD. Microfabricated drug delivery systems: from particles to pores [J]. Advanced Drug Delivery Reviews, 2003, 55: 315–328

DOI: 10.1016/s0169-409x(02)00227-2

[2] Huang WD, Sun WQ, Zheng QX, et al. Design and fabrication of drug delivery devices with complex architectures based on three-dimensional printing technique, Journal of Wuhan University of Technology-Materials Science Edition, 2005,20:85-88.

[3] Zheng QX, Guo XD, Du JY, et al. Biodegradation of Absorbable HA/dl-PLA Composites in Diferent Environment [J]. Joumal of Wuhan University of Technology-Mater.Sci.Ed, 2002, 17(3):24-29

[4] Huang WD, Yang XL. Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique，International Journal of Pharmaceutics, 2007,39:33-38.

DOI: 10.1016/j.ijpharm.2007.02.021

[5] Wu WG, Zheng QX, Guo XD, et al. The Controlled-releasing Drug Implant based on the Three Dimensional Printing Technology: Fabrication and Properties of Drug Releasing in vivo，Journal of Wuhan University of Technology-Materials Science Edition, 2009,24:977-981.

DOI: 10.1007/s11595-009-6977-1

[6] Jill KS, Susan LR, Robert P, et al. A three-dimensional osteochondral composite scaffold forarticular cartilage repair [J]. Biomaterials, 2002, 23: 4739–4751.

[7] Wu BM, Borland SW, Giordano RA, et al. Solid free-form fabrication of drug delivery devicess [J]. J Control Release, 1996, 40(1-2): 77-87.