Study on Biodegradable Implant with Poly (l-Lactic Acid) and its Releasing Character In Vitro
To elucidate the effects of implants fabricated by three-dimensional printing (3DP) technologies, a novel technique enables the complex implant release profiles, precise dosage control and rapid formulation in a single form. In this study, a unique implant with polylactic acid-based polymer powders was developed by the process. Test of the morphology and the releasing experiments in vitro of the implants were done to evaluate the implant devices. At about 100-day release of the implants in vitro, the drug concentration was measured and the profiles were made. The morphology of the implants of both technologies was characterized by three dimensional stereoscopy and environmental scanning electron microscope. The release behaviour and the microstructure were detected to compare the effects. 3DP technology allows the design and fabrication of implants with a novel micro- and macro-architecture which cannot be fabricated or may be fabricated with many difficulties in conventional technology.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
W. D. Huang et al., "Study on Biodegradable Implant with Poly (l-Lactic Acid) and its Releasing Character In Vitro", Advanced Materials Research, Vols. 236-238, pp. 2744-2747, 2011