Preparation and Characterization of Anti-HIV Drug TD0232-Loaded Microemulsion
The objective is to study the preparation of TD0232-loaded microemulsion (TD0232-ME) and its quality evaluation. The formulation was investigated by pseudoternary phase diagram. The loading capacity and entrapment efficiency was obtained by ultraviolet spectrophotometric method. The appearance，morphology，size distribution，stability of TD0232-ME were determined. The TD0232-ME，with good stability，was a transparent solution with visible sky-blue opalescence. TD0232-ME in transmission electronic microscopy (TEM) consisted of small spherical drops with a mean size of 30 - 50 nm. The UV analysis showed the loading capacity and encapsulated efficiency of TD0232-ME were 0.1% and 100%, respectively. The solubility of TD0232 was significantly increased in microemulsion and the stability was satisfying.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
H. J. Zhou et al., "Preparation and Characterization of Anti-HIV Drug TD0232-Loaded Microemulsion", Advanced Materials Research, Vols. 236-238, pp. 2825-2829, 2011