Preparation and Characterization of Anti-HIV Drug TD0232-Loaded Microemulsion

Hong Jing Zhou; Qiang Xia; Xing Mu Guo

doi:10.4028/www.scientific.net/AMR.236-238.2825

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Preparation and Characterization of Anti-HIV Drug TD0232-Loaded Microemulsion
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Preparation and Characterization of Anti-HIV Drug TD0232-Loaded Microemulsion

Abstract:

The objective is to study the preparation of TD0232-loaded microemulsion (TD0232-ME) and its quality evaluation. The formulation was investigated by pseudoternary phase diagram. The loading capacity and entrapment efficiency was obtained by ultraviolet spectrophotometric method. The appearance，morphology，size distribution，stability of TD0232-ME were determined. The TD0232-ME，with good stability，was a transparent solution with visible sky-blue opalescence. TD0232-ME in transmission electronic microscopy (TEM) consisted of small spherical drops with a mean size of 30 - 50 nm. The UV analysis showed the loading capacity and encapsulated efficiency of TD0232-ME were 0.1% and 100%, respectively. The solubility of TD0232 was significantly increased in microemulsion and the stability was satisfying.