Preparation and Characterization of Anti-HIV Drug TD0232-Loaded Microemulsion

Abstract:

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The objective is to study the preparation of TD0232-loaded microemulsion (TD0232-ME) and its quality evaluation. The formulation was investigated by pseudoternary phase diagram. The loading capacity and entrapment efficiency was obtained by ultraviolet spectrophotometric method. The appearance,morphology,size distribution,stability of TD0232-ME were determined. The TD0232-ME,with good stability,was a transparent solution with visible sky-blue opalescence. TD0232-ME in transmission electronic microscopy (TEM) consisted of small spherical drops with a mean size of 30 - 50 nm. The UV analysis showed the loading capacity and encapsulated efficiency of TD0232-ME were 0.1% and 100%, respectively. The solubility of TD0232 was significantly increased in microemulsion and the stability was satisfying.

Info:

Periodical:

Advanced Materials Research (Volumes 236-238)

Edited by:

Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao

Pages:

2825-2829

DOI:

10.4028/www.scientific.net/AMR.236-238.2825

Citation:

H. J. Zhou et al., "Preparation and Characterization of Anti-HIV Drug TD0232-Loaded Microemulsion", Advanced Materials Research, Vols. 236-238, pp. 2825-2829, 2011

Online since:

May 2011

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Price:

$35.00

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