Inclusion Complex of Dibenzoylmethane with β-Cyclodextrin
The inclusion complex of dibenzoylmathane(DBM)with β-cyclodextrin(β-CD)was studied. UV-spectrophotometer was used to investigate the complexation behaviour in liquid medium, and to demonstrate that the DBM aqueous solubility increased 7.27times due to complexation with β-CD and the inclusion rate of DBM was high to 95.92 percent and the drug-loading constant is also high to 37.86ug/g. Solid samples prepared by solution-agitating method. FT-IR was employed to assess the formation of the inclusion complex. Dissolution analysis indicated that dissolution properties of DBM/β-CD complex were superior compared to both pure DBM and the corresponding physical mixture of DBM and β-CD.
Zhong Cao, Xueqiang Cao, Lixian Sun, Yinghe He
X. Z. Ji et al., "Inclusion Complex of Dibenzoylmethane with β-Cyclodextrin", Advanced Materials Research, Vols. 239-242, pp. 1879-1882, 2011