Inclusion Complex of Dibenzoylmethane with β-Cyclodextrin

Abstract:

The inclusion complex of dibenzoylmathane(DBM)with β-cyclodextrin(β-CD)was studied. UV-spectrophotometer was used to investigate the complexation behaviour in liquid medium, and to demonstrate that the DBM aqueous solubility increased 7.27times due to complexation with β-CD and the inclusion rate of DBM was high to 95.92 percent and the drug-loading constant is also high to 37.86ug/g. Solid samples prepared by solution-agitating method. FT-IR was employed to assess the formation of the inclusion complex. Dissolution analysis indicated that dissolution properties of DBM/β-CD complex were superior compared to both pure DBM and the corresponding physical mixture of DBM and β-CD.

• Periodical: Advanced Materials Research (Volumes 239-242)
• Pages: 1879-1882
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.239-242.1879
• Online since: May 2011
• Authors: Xue Zhen Ji, Hui Jun Liu, Li Li Wang
• Keywords: Beta-Cyclodextrin, Dibenzoylmathane, Dissolution Properties, Inclusion Rate

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