Through the Quasi-Static test on two specimens of CFRST frame (KJ)and two specimens of CFRST frame with filler walls(TKJ) in horizontal load, the paper analyses the hysteretic curves of two structures contrastively, ductility, strength and stiffness degradation, consumption energy capacity, failure mechanism and failure characteristics, and also analyses the influence of various parameters on the seismic performance and the mechanical properties. The results show that the filler walls increase the stiffness of the structure, and especially in the early loading it is more significant. It is obvious to reduce the p-Δ effect of the column at the normal using stage. The deformability of frame without filler wall is greater than that of frame with filler wall. But the damage process of frame with filler wall is a flat curve, and it meets the demand of ductile frame. Through the hysteretic curve we can know that the dissipative energy capacity of frame without filler wall is good in contrast with that of frame with filler wall. Then the ductility factor of CFRST frame with filler wall is greater than that of RC frame with filler wall. So we can conclude that the CFRST frame has wonderful superiority on bearing capability, seismic behavior and effective use of material.