A novel building structure system, namely core-tube vibration-reduction suspended structure (CVRSS), is put forward in this paper. The basic composition and calculation model for the structure system are described. The El Centro and Taft seismic waves are used to calculate the dynamic characteristics of the structure in the time domain, of which dynamic responses are proved satisfactory. Taking the top floor displacement of the primary structure and the relative displacement between bottom layer of suspended segments and top floor of core-tube as objective function, the finite element model is established, and comparative analysis with common core-tube suspended structures (CCSS) is performed. The results show that the top floor displacement of CVRSS is about 70% of that of CCSS, and the vibration-reduction performance of CVRSS is excellent.