For analyzing reduction vibration effect of high-rise isolated structure with LRB, experimental research on shaking table of isolated structure model on a scale down of 1:16 in two-direction earthquake wave input was conducted. Ratio similitude design of model and earthquake wave input was unified for reflection dynamical characteristic of actual structure in the test. Earthquake responses of isolated top structure acceleration and interblended displacement have been analyzed. The experimental result indicts that isolated top structure acceleration and interblended displacement were reduced. Therefore the isolation technology for high-rise structure also has better reduction vibration effect.