Based on the hydrological, geologies and slope features of Jianshan phosphate mine in Yunnan province, the geomechanics model of slope was established. Then the static stability of different elevations in mining section was studied by using methods such as the rigid body limit equilibrium method, finite element method, continuum large deformation Lagrange element method. According to the supervise data of the mining blasting, the dynamic response of the slope in blasting was studied by continuum large deformation Lagrange element method, and some suggestions were proposed for following mining blasting. The research results show that the slope was in the stable status before blasting vibration. Current mining blasting vibration has little effect on the stability of slope, but would reduce the safety factor of the top of the slope. Single blasting would enlarge the instantaneous acceleration of the top of the slope in a ratio of 8.8% and 10.8%.