Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic

Abstract:

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Glutathione peroxidase (GPX) is a well-known selenoenzyme that can protect cells against oxidative damage. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was devised as a functional mimic of the GPX. The antioxidant effect of 2-TeCD was evaluated by its ability to protect mitochondria from oxidative damage. 2-TeCD could also suppress the TNF-α induced inflammatory effect on HUVECs surface in a dose-dependent manner. Meanwhile, 2-TeCD exhibited anti-proliferative property both in vitro and in vivo. These results indicate that 2-TeCD may be useful for developing medical agents in many pathological conditions such as cataract­, age-related diseases­, atherosclerosis, cancer and so on.

Info:

Periodical:

Advanced Materials Research (Volumes 282-283)

Edited by:

Helen Zhang and David Jin

Pages:

317-321

DOI:

10.4028/www.scientific.net/AMR.282-283.317

Citation:

T. T. Lin and J. Q. Liu, "Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic", Advanced Materials Research, Vols. 282-283, pp. 317-321, 2011

Online since:

July 2011

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Price:

$35.00

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