Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic

Ting Ting Lin; Jun Qiu Liu

doi:10.4028/www.scientific.net/AMR.282-283.317

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 282-283Synthesis, Antioxidant and Anticancer Activities...

Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic

Abstract:

Glutathione peroxidase (GPX) is a well-known selenoenzyme that can protect cells against oxidative damage. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was devised as a functional mimic of the GPX. The antioxidant effect of 2-TeCD was evaluated by its ability to protect mitochondria from oxidative damage. 2-TeCD could also suppress the TNF-α induced inflammatory effect on HUVECs surface in a dose-dependent manner. Meanwhile, 2-TeCD exhibited anti-proliferative property both in vitro and in vivo. These results indicate that 2-TeCD may be useful for developing medical agents in many pathological conditions such as cataract, age-related diseases, atherosclerosis, cancer and so on.

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Advanced Materials Research (Volumes 282-283)

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317-321

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https://doi.org/10.4028/www.scientific.net/AMR.282-283.317

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Online since:

July 2011

Authors:

Ting Ting Lin, Jun Qiu Liu

Keywords:

Anticancer, Antioxidant, Glutathione Peroxidase, Tellurium, Thioredoxin Reductase

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