Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic
Glutathione peroxidase (GPX) is a well-known selenoenzyme that can protect cells against oxidative damage. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was devised as a functional mimic of the GPX. The antioxidant effect of 2-TeCD was evaluated by its ability to protect mitochondria from oxidative damage. 2-TeCD could also suppress the TNF-α induced inflammatory effect on HUVECs surface in a dose-dependent manner. Meanwhile, 2-TeCD exhibited anti-proliferative property both in vitro and in vivo. These results indicate that 2-TeCD may be useful for developing medical agents in many pathological conditions such as cataract, age-related diseases, atherosclerosis, cancer and so on.
Helen Zhang and David Jin
T. T. Lin and J. Q. Liu, "Synthesis, Antioxidant and Anticancer Activities of Efficient Glutathione Peroxidase Mimic", Advanced Materials Research, Vols. 282-283, pp. 317-321, 2011