In order to study the performance of asphalt mixture with PR.S, Marshall test and rutting, low temperature bending, water stability test were done. The results indicated that the additive PR.S played an important role in improving high-temperature anti-rutting performance of asphalt mixture because of the cementation, reinforcement, inter-lock and adsorption function. With the amount of PR.S increasing, high-temperature performance of asphalt mixture increased gradually and low-temperature performance declined a little. In order to decide the appropriate amount of the additive PR.S, the low-temperature anti-cracking performance should be mainly considered when asphalt mixture was designed. The other performance of asphalt mixture with the amount of 0.45% PR.S could also meet the requirements of the specification. Considering its great contribution to anti-rutting, PR.S asphalt mixture was more properly adopted in the middle layer of asphalt pavement.