Multilayer materials produced by explosive welding of low carbon steel were investigated. Non-uniform structure of interlayer boundary was characterized using visible light microscopy, SEM and TEM. It was shown that 4 zones with different structure and mechanical properties present in the welded seams. To estimate fatigue properties of the multilayer materials kinetic diagram of fatigue failure were used. It was revealed that larger boundary waves give more significant contribution to fatigue crack resistance. In experiments carried out in the current research number of cycles to failure of multilayer materials was higher than those for bulk materials.