Application of Amniotic Extracellular Matrix Nerve Conduit with Biological Material in the Peripheral Nerve Defect In Vivo
Objective: To evaluate the peripheral nerve regeneration using a nerve conduit of amniotic extracellular matrix (AECM). Methods: 5 mm gap in the rabbit facial nerve was repaired with AECM conduit or with a silica gel conduit. After 7 days, 1 month and 3 months, the medullated nerve fibers and neural conductive velocity were determined. Results: On the 7th day, no neural regeneration was observed. But the neoformative neural fibers across AECM and silica gel were seen in the following 3 months, while the number and conductive velocity of medullated nerve fibers varied significantly at the different time points. Conclusion: AECM could repair the peripheral nerve defect.
Helen Zhang and David Jin
Z. Gao et al., "Application of Amniotic Extracellular Matrix Nerve Conduit with Biological Material in the Peripheral Nerve Defect In Vivo", Advanced Materials Research, Vol. 322, pp. 173-176, 2011