Application of Amniotic Extracellular Matrix Nerve Conduit with Biological Material in the Peripheral Nerve Defect In Vivo

Abstract:

Objective: To evaluate the peripheral nerve regeneration using a nerve conduit of amniotic extracellular matrix (AECM). Methods: 5 mm gap in the rabbit facial nerve was repaired with AECM conduit or with a silica gel conduit. After 7 days, 1 month and 3 months, the medullated nerve fibers and neural conductive velocity were determined. Results: On the 7th day, no neural regeneration was observed. But the neoformative neural fibers across AECM and silica gel were seen in the following 3 months, while the number and conductive velocity of medullated nerve fibers varied significantly at the different time points. Conclusion: AECM could repair the peripheral nerve defect.

• Periodical: Advanced Materials Research (Volume 322)
• Pages: 173-176
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.322.173
• Online since: August 2011
• Authors: Zhen Gao, Xiao Ting Luo, Nian Sheng Li, Wei Deng, Shu Mei Li
• Keywords: Amniotic Extracellular Matrix, Facial Nerve, Neural Regeneration, Silica Gel, Tissue Engineering

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