Application of Amniotic Extracellular Matrix Nerve Conduit with Biological Material in the Peripheral Nerve Defect In Vivo

Abstract:

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Objective: To evaluate the peripheral nerve regeneration using a nerve conduit of amniotic extracellular matrix (AECM). Methods: 5 mm gap in the rabbit facial nerve was repaired with AECM conduit or with a silica gel conduit. After 7 days, 1 month and 3 months, the medullated nerve fibers and neural conductive velocity were determined. Results: On the 7th day, no neural regeneration was observed. But the neoformative neural fibers across AECM and silica gel were seen in the following 3 months, while the number and conductive velocity of medullated nerve fibers varied significantly at the different time points. Conclusion: AECM could repair the peripheral nerve defect.

Info:

Periodical:

Edited by:

Helen Zhang and David Jin

Pages:

173-176

DOI:

10.4028/www.scientific.net/AMR.322.173

Citation:

Z. Gao et al., "Application of Amniotic Extracellular Matrix Nerve Conduit with Biological Material in the Peripheral Nerve Defect In Vivo", Advanced Materials Research, Vol. 322, pp. 173-176, 2011

Online since:

August 2011

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Price:

$35.00

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